Genome-Wide Association Study of Antiphospholipid Antibodies

Table 3

Genetic loci associated with the occurrence of lupus anticoagulant (LAC) with 𝑃<1𝐸−04*.

CHR	Gene	Lead SNP	BP	Total SNPs	MAF		OR	𝑃
					Negative	Positive
22	MICAL3	rs1978968	16828113	8	0.2144	0.3553	2.235	2.21𝐸−06
2	FAM176A	rs17011455	75643997	1	0.01661	0.06967	5.211	4.70𝐸−06
20	DSTN	rs17791782	17514069	2	0.07867	0.1721	2.628	6.54𝐸−06
6	SUPT3H	rs9472374	44904278	1	0.01957	0.07083	4.77	1.14𝐸−05
3	LRIG1	rs4549225	66850149	10	0.3735	0.5246	1.867	1.54𝐸−05
1	SMYD3	rs7527610	2.45𝐸+08	2	0.005236	0.04098	10.19	1.77𝐸−05
14	PELI2	rs754314	55822350	8	0.04833	0.1167	3.111	2.13𝐸−05
20	BFSP1	rs16999416	17489830	1	0.08494	0.1777	2.412	2.32𝐸−05
16	NDRG4	rs11862356	57067820	1	0.05846	0.1393	2.745	2.40𝐸−05
17	CDRT15P1	rs7208809	13678048	2	0.06806	0.1516	2.573	2.62𝐸−05
22	FAM19A5	rs9615320	47219591	2	0.1065	0.2008	2.333	3.07𝐸−05
6	SNRNP48	rs17398435	7549105	1	0.06392	0.1446	2.589	3.45𝐸−05
14	OTX2	rs12897597	56314078	1	0.1531	0.2667	2.097	3.53𝐸−05
17	RBFOX3	rs16972153	74719776	1	0.04974	0.1148	2.925	3.59𝐸−05
16	MAF	rs9935211	78440577	5	0.05467	0.1311	2.692	4.18𝐸−05
5	YTHDC2	rs6865651	1.13𝐸+08	2	0.1848	0.3058	2.005	4.32𝐸−05
10	LDB3	rs4934256	88490345	2	0.05507	0.123	2.783	4.68𝐸−05
9	KLF4	rs1888617	1.1𝐸+08	1	0.2657	0.4009	1.935	4.92𝐸−05
10	TACC2	rs12773310	1.24𝐸+08	6	0.3536	0.219	0.4945	5.19𝐸−05
6	LY86	rs9328374	6536628	1	0.1875	0.307	1.989	5.40𝐸−05
9	ZCCHC7	rs7031314	37366122	3	0.2204	0.3375	1.924	5.90𝐸−05
3	SETD5	rs17050346	9456593	5	0.01926	0.06967	4.047	6.34𝐸−05
4	COL25A1	rs13104799	1.1𝐸+08	6	0.2245	0.1107	0.4106	6.68𝐸−05
7	C7orf58	rs12537243	1.2𝐸+08	1	0.09178	0.1736	2.289	7.22𝐸−05
4	RBM46	rs7687314	1.56𝐸+08	6	0.4474	0.5902	1.808	7.25𝐸−05
9	LOC100506710	rs10973184	37056617	1	0.09895	0.1885	2.252	7.33𝐸−05
3	EPHA6	rs4318565	97564200	1	0.03369	0.08607	3.32	7.77𝐸−05
11	LOC283143	rs1393275	1.15𝐸+08	3	0.05026	0.1261	2.595	7.90𝐸−05
18	MAPRE2	rs573269	30863716	1	0.3129	0.4385	1.816	8.05𝐸−05
13	FARP1	rs285031	97584032	1	0.1489	0.2438	2.092	8.11𝐸−05
10	ANXA2P3	rs10822492	66751936	15	0.3439	0.219	0.5075	8.32𝐸−05
6	TBCC	rs11759402	42831787	4	0.1658	0.2686	1.945	8.32𝐸−05
4	LNX1	rs6831173	54085908	4	0.1337	0.2377	1.962	8.80𝐸−05
4	SLC7A11	rs10440463	1.39𝐸+08	3	0.2073	0.3238	1.88	8.85𝐸−05
1	HHAT	rs1028383	2.09𝐸+08	1	0.2248	0.3475	1.882	9.29𝐸−05
11	WT1	rs2207549	32325033	2	0.4202	0.2833	0.5274	9.37𝐸−05
4	FAM198B	rs17036867	1.59𝐸+08	12	0.02747	0.08621	3.54	9.54𝐸−05

∗CHR: chromosome; Gene: a plausible biological candidate gene in the locus or the nearest annotated gene to the lead SNP; Lead SNP: most significant SNP in the gene region; BP: base-pair position of the lead SNP; Total SNPs: total number of SNPs with 𝑃<1𝐸−03 in the gene region; MAF: minor allele frequencies in antibody-negative and antibody-positive groups; OR: odds ratio; 𝑃: 𝑃-values for the test.