Genome-Wide Association Study of Antiphospholipid Antibodies
Table 5
Genetic loci associated with the occurrence of two or more antiphospholipid antibodies (ACL, LAC, or Anti-GPI) with *.
CHR
Gene
Lead SNP
BP
Total SNPs
MAF
OR
Negative
Positive
16
DYNLRB2
rs8060581
78750106
6
0.02466
0.1406
6.714
2
SESTD1
rs13403289
179924976
2
0.3857
0.5833
2.423
1
DNAH14
rs3913653
223603694
11
0.543
0.3421
0.43
10
CACNB2
rs10828616
18710023
6
0.2175
0.3698
2.538
18
EPB41L3
rs7238186
5469093
2
0.213
0.3854
2.327
1
MAGI3
rs11102625
113750976
5
0.4355
0.6146
2.298
2
TANK
rs13010671
161593338
5
0.07442
0.1882
3.437
7
CNTNAP2
rs12113442
145329124
1
0.1054
0.2188
2.938
18
ZNF519
rs8093228
13989380
4
0.2152
0.3646
2.326
3
FAM198A
rs7624799
43020807
3
0.1592
0.2969
2.466
20
DSTN
rs17791782
17514069
2
0.07883
0.1927
3.086
20
BFSP1
rs16999416
17489830
1
0.08371
0.2031
2.93
13
ANKRD20A9P
rs7319595
18392986
1
0.3484
0.5213
2.337
15
TLE3
rs10518889
68337482
4
0.2838
0.4427
2.231
22
CLTCL1
rs8135222
17672446
1
0.1749
0.3281
2.293
11
TMEM45B
rs10894119
129081436
1
0.1789
0.3158
2.432
1
GADD45A
rs787480
67868460
1
0.2207
0.08854
0.3088
20
SPTLC3
rs6105044
13065747
2
0.352
0.1979
0.4138
6
HIVEP1
rs6908010
12325985
2
0.4753
0.3073
0.4688
7
CUX1
rs427534
101673424
3
0.4439
0.2656
0.4569
10
MSMB
rs7094791
51229942
1
0.3857
0.2396
0.4081
8
TPD52
rs10090469
81396522
1
0.1099
0.2292
2.668
14
LOC100506433
rs698322
47597316
1
0.3914
0.2344
0.4277
6
MMS22L
rs1206164
97703068
1
0.2511
0.4219
2.212
12
CDK17
rs11108526
95379901
2
0.02691
0.08333
5.95
11
PDGFD
rs4754095
103278377
3
0.2851
0.1436
0.3771
15
FMN1
rs2444955
31199305
2
0.1951
0.3474
2.408
10
SORCS1
rs4918273
108715485
11
0.3597
0.5319
2.064
CHR: chromosome; Gene: a plausible biological candidate gene in the locus or the nearest annotated gene to the lead SNP; Lead SNP: most significant SNP in the gene region; BP: base-pair position of the lead SNP; Total SNPs: total number of SNPs with in the gene region; MAF: minor allele frequencies in antibody-negative (negative for ALC, ACL and anti-GPI) and antibody-positive (positive for at least two of ALC, ACL or anti-GPI) groups; OR: odds ratio; : -values for the test.
