Genes Associated with SLE Are Targets of Recent Positive Selection

Table 4

Summary of regions with evidence for selection on both the HapMap and HGDP populations.

Gene region	HapMap					HGDP
	iHS	𝐷	𝐹ST		Min empirical 𝑃 value	𝐹ST	iHS	XP-EHH
		Max −log(𝑄)	Max −log(𝑄)	Value		Max −log(𝑃)	Max −log(𝑃)	Max −log(𝑃)
PTPN22		3.6	3.2	0.75			3.0	3.5
TNFSF4				0.6	0.005	4.5
TET3, DGUOK			3.2	0.85	0.001			3.5
TNIP1		3.0		0.65		3.5		3.0
UHRF1BP1	|2.28|^∗				0.004		3.0	3.5
BLK				0.92	0.005	4.0	3.0	4.0
ITGAM			3.4	0.75				3.5

Please refer to footnotes on Tables 2 and 3 for details. ^∗iHS=−2.28 for rs11755393.