The Role of Decay Accelerating Factor in Environmentally Induced and Idiopathic Systemic Autoimmune Disease
Figure 5
Hypothetical DAF function during T-cell costimulation. Conventional T-cell activation via CD28 cross-linking leads to the formation of lipid raft clusters which exclude CD55 (a) resulting in proinflammatory (i.e., IFN-) cytokine production which, under suitable conditions, may lead to Th1-mediated autoimmunity such as mHgIA. Conversely, increasing the surface density of DAF leads to less efficient CD28-mediated T cell activation (b) and in the presence of CD97 potentiates CD55 signaling leading to increased production of IL-10, a T regulatory cell phenotype and immune tolerance.
