The Role of Decay Accelerating Factor in Environmentally Induced and Idiopathic Systemic Autoimmune Disease

Table 1

Decreased DAF expression in human disease.

Disease	Cell surface DAF deficiency	Citation
Immune dysregulation
Sjogren’s Syndrome	T-lymphocytes	[36]
SLE with lymphopenia and anemia	T-lymphocytes (CD8+), endothelium,; lymphocytes, and anemia	[38, 41, 73]
Psoriatic skin	Epithelium and endothelium	[39]
Systemic sclerosis	Endothelium	[37]
Vasculitic skin lesions	Endothelium	[35]
Recurrent pregnancy loss in aPL	Endometrium	[42]
Autoimmune hemocytopenia	Platelets, lymphocytes, and RBC	[43, 44]
Rheumatoid arthritis	Neutrophils and RBC	[45, 46]
Myasthenia gravis	SNP with decreased expression	[47]
Vitiligo	Whole epidermis	[48]
Asthma	Bronchial epithelial cells and SNP	[49, 50]
Proliferative disorders
Myelodysplastic syndrome	Granulocytes and RBC	[51, 52]
Plasma cell dyscrasias	RBC	[53]
Lymphoproliferative disorders	RBC	[54]
Anemias
Anemia of malaria	RBC	[55–59]
Aplastic anemia	RBC	[51]
HIV	RBC, lymphocytes, and PBMC	[60, 61]

RBC: red blood cell; SNP: single-nucleotide polymorphism; aPL: antiphospholipid; PBMC: peripheral blood mononuclear cell.