CD8+DR+ T-Cells and C3 Complement Serum Concentration as Potential Biomarkers in Thrombotic Antiphospholipid Syndrome

Table 2

Concentration and functional activity of complement proteins in patients with thrombotic APS and healthy controls.

Parameter	Patients	aPL positive controls	SLE controls	Healthy controls	P
	(𝑛=38)	(𝑛=14)	(𝑛=16)	(𝑛=52)
C3, mean ± SD; mg/dL (range)	97.7 ± 26.3; (58–156)	108.8 ± 39; (61–202)	77 ± 20; (27–106)	113.4 ± 40.6; (61–305)	0.35^a, 0.05^b, 0.04^c
Low C3 (%)^1	41.2	30.8	43.8	19.2	0.74^a, 0.76^b, 0.04^c
C4, mean ± SD; mg/dL (range)	16.9 ± 8.5; (2–41)	21 ± 7; (12–35)	15 ± 6; (5–27)	23.9 ± 9.6; (12.8–74.4)	0.19^a, 0.58^b, 0.001^c
Low C4 (%)^2	63.9	38.5	56.3	17.3	0.14^a, 0.77^b, <0.01^c
FB, mean ± SD; mg/dL (range)	33 ± 7.7; (14–46.1)	31 ± 8; (21.9–47.1)	28 ± 6; (23–34)	31.0 ± 8.27; (20–63)	0.83^a, 0.45^b, 0.28^c
Low FB (%)^3	3.33	0	0	0	0.54^a, 0.83^b, 0.37^c
CH100, mean ± SD; Units/mL (range)	46.9 ± 17.9; (20–70)	60 ± 27; (23–89)	63 ± 24; (36–102)	70.5 ± 31.5; (20–165)	0.19^a, 0.23^b, 0.01^c
Low CH100 (%)^4	64.3	57.1	71.4	59.4	0.37^a, 0.63^b, 0.51^c

APS: antiphospholipid syndrome; aPL positive controls: aPL+ patients without APS clinical criteria; HC: healthy controls; FB: factor B; ¹C3 normal range: 83–172 mg/dL; ²C4 normal range: 17–51 mg/dL; ³FB normal range: 19–50 mg/dL; ⁴CH100 normal range: >70 units/mL. ^aANOVA comparison of thrombotic APS with aPL+ controls, ^bANOVA comparison of thrombotic APS with SLE controls, and ^cANOVA comparison of thrombotic APS with healthy controls.