Exploring T Cell Reactivity to Gliadin in Young Children with Newly Diagnosed Celiac Disease
Figure 3
Proliferation of unfractionated PBMCs with -gliadin peptides. (a) Representative data from three newly diagnosed Celiac subjects with 7-day CFSE proliferation assays. CD4 T cells proliferate in response to the -gliadin p1E deamidated peptide without the in vitro addition of cytokines. (b) Summary data of proliferative responses comparing CFSE only (no antigen background) to the -gliadin p1E peptide. (c) Proliferation of native -gliadin to the -gliadin p1E deamidated peptide. using a paired -test. Pentacel (positive control) is a childhood vaccine containing immunogens directed against diphtheria, tetanus, pertussis, poliomyelitis, and Haemophilus influenzae type b.
