Exploring T Cell Reactivity to Gliadin in Young Children with Newly Diagnosed Celiac Disease
Figure 4
Proliferation of PBMCs from newly diagnosed Celiac patients to - and -gliadin peptides.(a) Proliferative responses to -gliadin and (b) -gliadin epitopes. Celiac subjects proliferate more in response to -gliadin peptides compared to -gliadin, especially the peptide deamidated at pocket 1 in which 6/10 subjects responded. Overall, there are 12/60 responses to -gliadin peptides compared to 3/50 for -gliadin ( with a Fisher’s exact test). Dotted line is at a stimulation index ( cells at background/peptide condition) of 3, above which a responder is considered.
