Exploring T Cell Reactivity to Gliadin in Young Children with Newly Diagnosed Celiac Disease

Table 3

Overview of the T cell responses to tested DQ2 and DQ8 gliadin epitopes.

Peripheral T cell responses as measured by CD4⁺CFSE^lo proliferated cells for each individual with correlation to HLA-DQ genotype. Black boxes represent a response to the peptide with the SI ≥ 3. Gliadin epitopes are denoted as previously reported in the literature to be presented by HLA-DQ2 (𝛼-I gliadin57--68 QLQPFPQPELPY, 𝛼-II gliadin62--73 PQPELPYPQPQL, and 𝛾-1 gliadin139--152 PEQPQQSFPEQERP) or HLA-DQ8 (𝛼-gliadin228--240 SGQGSFQPSQQNP and 𝛾-gliadin65--79 FPQQPQQPYPQQPQQ with and without deamidation at p1 and p9). Three of the new-onset CD children responding to two or more peptides have the DQ2/2 genotype.