Is Dopamine an Iatrogenic Disruptor of Thyroid and Cortisol Function in the Extremely Premature Infant?

Table 2

Multivariable regression analyses of factors affecting FT4: lowest MAP, dopamine exposure, CRIB score, gestation, and highest plasma lactate concentration.

Predictor variables	𝐵 coefficient	95% confidence interval for 𝐵	𝑃 value
Lowest MAP (mm Hg)	0.13	−0.21 to 0.46	0.46
Dopamine	−3.77	−7.29 to −0.25	0.03
CRIB score	−0.31	0.04 to 1.09	0.04
Gestation (weeks)	2.83	1.22 to 4.45	0.01
Highest lactate (mmol/L)	−0.23	−0.60 to 0.55	0.94

Stepwise model: dependent variable FT4, predictor variables entered: lowest MAP, dopamine, CRIB score, gestation, and highest lactate. Constant intercept = 17.26. Adjusted 𝑅 square =0.72; 𝐹=72.6, 𝑃=0.01 (using stepwise model).