Advances in Epidemiology http://www.hindawi.com The latest articles from Hindawi Publishing Corporation © 2014 , Hindawi Publishing Corporation . All rights reserved. Estimating Cancer Latency Times Using a Weibull Model Sun, 31 Aug 2014 09:21:56 +0000 http://www.hindawi.com/journals/aep/2014/746769/ Mathematical models can be useful tools in exploring population disease trends over time and can be used to gain insight into the fundamental mechanisms of cancer development. In this paper, we provide a systematic comparison between the exact and the approximate solutions for estimating the length of time between the biological initiation of cancer and diagnosis through the development of a Weibull-like survival model. A total of 1,608,484 malignant primary cancers were used in the analysis using cancer incidence data obtained from the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) program. We find that the approximate solution provides a reliable comparison of the latency periods for different types of cancer and has no significant effect on the estimation accuracy, which differs from the exact solution by 0% to 11.3%. Thirty-five of the 44 cancers in this analysis were found to progress silently for 10 years or longer prior to detection representing 89% of the patients in this analysis. The results of this analysis differentiate cancer types that progress undetected over a period of years to identify new opportunities for early detection which increases the likelihood of successful treatment and alleviates the ever-growing cancer burden. Diana L. Nadler and Igor G. Zurbenko Copyright © 2014 Diana L. Nadler and Igor G. Zurbenko. All rights reserved. Predictors of Work-Related Musculoskeletal Disorders among Commercial Minibus Drivers in Accra Metropolis, Ghana Thu, 21 Aug 2014 09:39:43 +0000 http://www.hindawi.com/journals/aep/2014/384279/ Background. The objective of this study is to determine the prevalence and predictors of work-related musculoskeletal disorders (WMSDs) among a sample of commercial minibus drivers in the Accra Metropolis of Ghana. Methods. The participating drivers () were recruited from various lorry terminals and assessed by using a semistructured questionnaire that included the Nordic Musculoskeletal Questionnaire (NMQ). Results. Of the 148 drivers, 116 (78.4%) reported having WMSDs during the previous 12 months. The prevalence of the various WMSD domains was low back pain (58.8%), neck pain (25%), upper back pain (22.3%), shoulder pain (18.2%), knee pain (14.9%), ankle pain (9.5%), wrist pain (7.4%), elbow pain (4.7%), and hip/thigh pain (2.7%). Multiple logistic regression analysis adjusted for possible confounders showed that less physical activity (OR = 4.9; 95% CI = 1.5–16.5; ), driving more than 12 hours per day (OR = 2.9; 95% CI = 1.1–7.8; ), and driving at least 5 days per week (OR = 3.7; 95% CI = 1.4–9.4; ) were significantly associated with WMSDs among this cohort of drivers. Conclusion. These modifiable factors may be targets for preventive strategies to reduce the incidence of WMSDs among occupational minibus drivers in Ghana. J. K. Abledu, E. B. Offei, and G. K. Abledu Copyright © 2014 J. K. Abledu et al. All rights reserved. Metabolic Syndrome according to Three Definitions in Hammam-Sousse Sahloul Heart Study: A City Based Tunisian Study Tue, 05 Aug 2014 00:00:00 +0000 http://www.hindawi.com/journals/aep/2014/891297/ Objectives. Metabolic syndrome (MetS) is a major risk factor of CVD. The aim of the present study is to determine the prevalence of the MetS, its components, and its different profiles according to NCEP-ATP III 2001, IDF 2005, and JIS 2009 definitions in Hammam-Sousse Sahloul Heart Study (HSHS). Study Design. The study involved 1121 participants (364 men and 757 women; sex-ratio  =  0.48; mean age  =  47.49 ± 16.24 years) living in Hammam Sousse city, located in the east of Tunisia. Methods. Anthropometric parameters, blood pressure, lipids levels, glycemia, insulinemia, and body mass index were measured. Statistical analyses were performed by SPSS16.0. Results. The percentage of participants who had MetS defined according to NCEP ATP III, IDF 2005, and JIS 2009 definitions was respectively, 29.5%, 38.4%, and 39.6%. With regard to gender, the prevalence of MetS is higher in men than in women according to IDF 2005 definition (38.5% men versus 38.3% women, ) and according to JIS 2009 definition (41.8% men versus 38.6% women, ), whereas, according to NCEP ATP III definition, the prevalence of MetS is higher in women than in men (30% versus 28.6%, ). The prevalence of MetS increased with increasing age according to the three definitions () and peaked in the oldest age group (≥70 years) according to IDF 2005 and JIS 2009. Furthermore, a significant difference in the prevalence of MetS components according to gender was observed. Indeed, the abdominal obesity is the most frequent MetS compound in women group, but hypertension and low HDL-C are the most frequent in men. In addition, according to the three definitions, the most frequent MetS profile in our study is “higher waist circumference, hypertension, and low HDL-C.” Conclusion. The high prevalence of MetS is a serious public health problem in Hammam-Sousse Sahloul community. Higher waist circumference, hypertension, and low HDL-C were the most frequent profile in our study. Imen Boumaiza, Asma Omezzine, Meriem Romdhane, Jihène Rejeb, Lamia Rebhi, Lobna Bouacida, Souhir Neffati, Nabila Ben Rejeb, Ahmed Ben Abdelaziz, and Ali Bouslama Copyright © 2014 Imen Boumaiza et al. All rights reserved. Isoniazid Preventive Therapy Adherence and Associated Factors among HIV Positive Patients in Addis Ababa, Ethiopia Tue, 22 Jul 2014 11:27:37 +0000 http://www.hindawi.com/journals/aep/2014/230587/ Tuberculosis coinfected with HIV constitutes a large proportion of patients in Ethiopia. Isoniazid preventive therapy (IPT) is recommended for the treatment of latent tuberculosis infection. However, the level of IPT adherence and associated factors among people living with HIV (PLHIV) have not been well explored. This study aimed to assess adherence to IPT and associated factors among PLHIV in Addis Ababa. Facility based cross-sectional study was conducted. The study was conducted in 10 health centers and 2 hospitals. Patients were consecutively recruited till the required sample size was obtained. From 406 PLHIV approached, a total of 381 patients on IPT were interviewed. Data were entered and analyzed using Epi-Info version 3.5 and SPSS version 16. The level of adherence to IPT was 89.5%. Patients who have taken isoniazid for ≥5 months were more likely to be adherent than those who took it for 1-2 months [AOR (95%CI) = 5.09 (1.41–18.36)]. Patients whose friends decide for them to start IPT were less likely to be adherent than others [AOR (95%CI) = 0.10 (0.01–0.82)]. The level of adherence to IPT in PLHIV was high. Counseling of patients who are in their first two months of therapy should be more strengthened. Strong Information Education Communication is essential to further enhance adherence. Melaku Berhe, Meaza Demissie, and Gezahegn Tesfaye Copyright © 2014 Melaku Berhe et al. All rights reserved. Malarial Infection in HIV Infected Pregnant Women Attending a Rural Antenatal Clinic in Nigeria Thu, 17 Jul 2014 07:50:33 +0000 http://www.hindawi.com/journals/aep/2014/694213/ Malaria still remains a challenging infection affecting the lives of several HIV infected pregnant women in sub-Saharan Africa. This study was undertaken to determine malarial infection in HIV infected pregnant women in relation to sociodemographic and obstetrical factors. The study also assessed relationship between malarial infection and haemoglobin level, counts, and ART regimen, as well as predisposing risk factors that influenced occurrence of malarial infection in the women. Thick and thin blood smears were prepared and stained with Giemsa. Haemoglobin level was determined using a hematology analyzer, while the flow cytometry was used to measure counts. Sociodemographic and obstetrical parameters were obtained through the administration of questionnaires. Of the 159 HIV infected pregnant women examined, 33.3% (59/159) had malarial infection. Malarial infection was significantly higher in pregnant women who were divorced, 40.24% (33/82) , were at their first trimester (4–12 weeks), 54.8% (17/31) , had  = [201–500 cells/μL], 42.42% (42/99) , and those that had severe anaemia (<8 dg/L), 100.00% . However, risk factors that influenced the occurrence of malarial infection in the pregnant women were occupation (farming) , marital status (divorced) , gestation (first trimester) , haemoglobin level (Hb < 8 dg/L) , and counts (low ) . The study reported endemicity of malaria in HIV infected pregnant women living in rural areas of Benue State, Nigeria. Malarial infection was higher in women that were divorced, and at their first trimester, had low count, and had severe anaemia. Farming, divorce, gestation, severe anaemia, and low counts were predisposing risk factors that influenced malaria occurrence in the HIV infected pregnant women. It is advocated that HIV infected pregnant women should be properly and thoroughly educated on malaria preventive measures in rural areas so as to avoid unpleasant effect of malaria during their pregnancies. R. S. Houmsou, B. E. Wama, S. O. Elkanah, L. C. Garba, T. D. Hile, J. B. Bingbeng, S. L. Kela, and E. U. Amuta Copyright © 2014 R. S. Houmsou et al. All rights reserved. Paternal Occupational Exposure to Endocrine-Disrupting Chemicals as a Risk Factor for Leukaemia in Children: A Case-Control Study from the North of England Wed, 16 Jul 2014 12:20:47 +0000 http://www.hindawi.com/journals/aep/2014/323189/ Occupations with exposures to a variety of chemicals, including those thought to be potential endocrine disruptors, have been associated with an increased risk of leukaemia in offspring. We investigated whether an association exists between paternal occupations at birth involving such exposures and risk of leukaemia in offspring. Cases () were matched, on sex and year of birth, to controls from two independent sources, one other cancers, one cancer-free live births. Paternal occupations at birth were classified, using an occupational exposure matrix, as having “very unlikely,” “possible,” or “likely” exposure to six groups of potential endocrine-disrupting chemicals. There was a significantly increased risk of acute nonlymphocytic leukaemia (ANLL) for polychlorinated organic compounds (OR 1.95, 95% CI 1.08–3.54) only in comparison with cancer-free controls, and for phthalates (OR 1.61, 95% CI 1.00–2.61) only with registry controls. A number of other, including inverse, associations were seen, but limited to one control group only. No associations were seen with likely paternal exposure to heavy metals. The associations identified in this study require further investigation, with better exposure and potential confounding (for example maternal variables) information, to evaluate the likelihood of true associations to assess whether they are real or due to chance. Mark S. Pearce, Lucy R. Baxter, and Louise Parker Copyright © 2014 Mark S. Pearce et al. All rights reserved.