|
| Heavy metals | Animal organs or culture cells | Effects | Ref. no. (year) |
|
| As (Sodium arsenite) | Human lung carcinoma A 549 cells | Inhibition of 8-oxo-Gua base excision repair activity and hOGG1 expression | [21] (2002) |
| As (arsenic trioxide, sodium arsenite, sodium arsenate) | Mouse nonparenchymal hepatocyte NCTC | Fragmentation of mOGG1 | [24] (2006) |
| Cd (Cadmium chloride) | Testis of Sprague-Dawley rat (♂, 8-week-old) | Inhibition of 8-oxo-Gua base excision repair activity | [20] (1997) |
| Cd (Cadmium acetate) | Testis of F344/NCr rat (♂, 6-7-week-old) | Inhibition of 8-oxo-dGTPase activity | [23] (1999) |
| Cd (Cd aerosol for rats, Cadmium chloride for cultured cells) | Lung of Lewis rat (♂, 185 ± 5 g), Adult rat lung epithelial cell line | Down-regulation of hOGG1 | [30] (2003) |
| Cd (Cadmium chloride) | Human fibroblast GM00637, HeLa S3 cell | Down-regulation of hOGG1 | [22] (2005) |
| Cd (Cadmium chloride) | TM3 cell (mouse testicular Leydig cell line) | Down-regulation of OGG1 and MUTYH | [25] (2009) |
| Cr (Sodium dichromate) | Human lung carcinoma A 549 cells | Down-regulation of hOGG1 | [26] (2002) |
| Cr (Sodium dichromate) | White blood cells of healthy adult volunteers () | Decrease in Ser326Cys OGG1 activity | [27] (2005) |
| Mn (Manganese chloride) | PC12-derived neuronal cells | Decrease in OGG1 activity | [28] (2004) |
| Pb (Lead acetate) | Brain of timed-pregnant Long-Evans rat | Decrease in OGG1 activity up to 12 months of age and increase between 12 and 20 months of age | [29] (2006) |
|
