Review Article

CREB: A Key Regulator of Normal and Neoplastic Hematopoiesis

Figure 1

Pathways for CREB activation in hematopoietic cells. A variety of extracellular stimuli promote CREB activation through phosphorylation or through interaction with CREB coactivators to enhance the expression of CREB responsive genes. CREB target genes have been shown to mediate effects on cellular proliferation, apoptosis, survival, and differentiation. PLC : phospholipase-C, DAG : 1,2-diacylglycerol, PKC- : protein kinase C- .
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