ETV6-RUNX1 Rearrangement in Tunisian Pediatric B-Lineage Acute Lymphoblastic Leukemia

Table 1

Summary of patients with abnormal FISH findings.

Patients	Age/sex (years)	Karyotype (number of cells)	FISH signals (No.)			% of cells
			ETV6	RUNX1	ETV6-RUNX1 fusion
1	13/M	46, XY[20]	0	1	2	15
2	2/M	46, XY[16]	0	1	1	16
3	5/M	46, XY, del(20)(p12)[8]/46, XY[10]	1	1	2	17
4	6/M	46, XY[19]	1	2	1	25
5	3/F	46, X, −X, add(3)(q27), + mar[5]/46, XX[15]	3	3	0	18
6	15/F	48, XX, t(2;11)(p12;q23), +20, +21[18]	2	3	0	24
7	13/M	46, XY, −16, +mar[9]/46, XX[6]	2	3/4	0	14
8	2/F	46, XX[20]	2	4	0	19
9	7/M	46, XY[20]	1	1	1	14
10	4/F	46, XX[21]	1	1	1	23
11	14/M	46, XY[20]	1	1	1	32
12	4/F	46, XX[21]	1	1	1	17
13	4/F	46, XX[17]	1	1	1	15
14	5/M	46, XY[21]	1	2	1	44
15	3.5/F	46, XX[19]	1	1	1	22
16	14/M	46, XX, −1, dic(1;16)(p31;p13)X2,−21,+2mar[16]	2	3	0	14
17	13/M	47, XXY, del(12)(p12−p13)[8]/47, XXY[12]	2	3	0	16
18	7/F	47, XX, +5[9]/46, XX[3]	1	1	1	17
19	8/M	46, XY[18]	1	1	1	27
20	4/F	No metaphases	1	1	1	41
21^a	4/F	46, XX[17]	1	1	1	18
22	3/M	46, XY[19]	1	1	1	22
23	1.2/M	46, XY[19]	2	3	0	14

^aThis case harbored two distinct clones: one with only the ETV6/RUNX1 rearrangement and the second (9% of cells) with an extra signal of RUNX1 gene.
No: number.