Research Article
Comorbidities of Idiopathic Thrombocytopenic Purpura: A Population-Based Study
Table 5
Rate ratios and 95% CI between ITP and non-ITP patients for 26 grouped medical conditions.
| (a) |
| | Comorbidity group | Ratio ITP/non-ITP | | [5 4[ | [4 3[ | [3 2[ | [2 1[ | [1 diag[ |
| | Rate ratio | Lower CI | Upper CI | Rate ratio | Lower CI | Upper CI | Rate ratio | Lower CI | Upper CI | Rate ratio | Lower CI | Upper CI | Rate ratio | Lower CI | Upper CI |
| | CASMI | 1.4 | 0.3 | 7.4 | 0.9 | 0.2 | 4.3 | 2.7 | 0.9 | 7.8 | 3.1 | 1.0 | 9.3 | 4.0 | 1.7 | 9.5 | | PVD | 1.7 | 0.6 | 4.8 | 1.1 | 0.3 | 4.0 | 3.0 | 0.9 | 10.0 | 4.6 | 1.8 | 11.6 | 1.5 | 0.5 | 4.4 | | Heme | 2.8 | 1.3 | 5.7 | 2.2 | 1.0 | 5.0 | 3.0 | 1.4 | 6.2 | 2.1 | 1.1 | 4.0 | 4.9 | 3.2 | 7.6 | | Renal | NA | — | — | 0.0 | — | — | NA | — | — | 3.6 | 0.2 | 57.3 | 7.2 | 0.7 | 79.1 | | Pulmonary | 12 | 0.1 | 11.5 | 0.0 | — | — | 7.2 | 0.7 | 79.1 | 4.8 | 1.1 | 21.4 | 1.2 | 0.3 | 4.4 | | Oral | 1.4 | 0.7 | 2.7 | 1.5 | 0.7 | 3.2 | 0.9 | 0.4 | 2.2 | 1.1 | 0.6 | 2.2 | 2.8 | 1.4 | 5.3 | | Ophthalmologic | 2.3 | 0.9 | 5.9 | 1.4 | 0.5 | 3.9 | 1.3 | 0.5 | 3.2 | 1.5 | 0.7 | 3.5 | 2.6 | 1.2 | 5.4 | | Neurological | 0.0 | — | — | 0.7 | 0.1 | 6.1 | 3.6 | 0.5 | 25.4 | 4.8 | 1.1 | 21.4 | 7.2 | 1.8 | 28.8 | | Neoplasm | 3.6 | 0.2 | 57.4 | 1.8 | 0.2 | 19.8 | NA | — | — | 0.0 | — | — | 0.7 | 0.1 | 6.1 | | Musculo-skeletal | 1.6 | 0.7 | 3.7 | 1.0 | 0.3 | 3.1 | 1.3 | 0.6 | 3.2 | 1.4 | 0.5 | 3.5 | 2.6 | 1.3 | 5.3 | | Mood disorder | 1.8 | 0.4 | 7.2 | 0.0 | — | — | 3.6 | 0.2 | 57.3 | 0.0 | — | — | Inf | — | — | | Infections | 1.3 | 0.6 | 2.8 | 1.3 | 0.6 | 2.8 | 1.4 | 0.6 | 2.9 | 1.4 | 0.8 | 2.5 | 2.9 | 1.8 | 4.6 | | Hypoglycemia | 0.0 | — | — | NA | — | — | Inf | — | — | 0.0 | — | — | 3.6 | 0.2 | 57.3 | | Hypersensitivity | 4.8 | 1.1 | 21.4 | 1.4 | 0.3 | 7.4 | 2.7 | 0.6 | 12.1 | 0.0 | — | — | 0.7 | 0.2 | 3.3 | | GU | 3.6 | 0.7 | 17.8 | 1.2 | 0.3 | 4.4 | 2.1 | 0.6 | 7.0 | 0.4 | 0.1 | 2.0 | 1.0 | 0.3 | 3.1 | | GI | 0.9 | 0.4 | 2.3 | 1.4 | 0.7 | 2.7 | 0.9 | 0.4 | 2.0 | 1.8 | 1.0 | 3.0 | 2.4 | 1.5 | 3.9 | | Edema | 1.6 | 0.6 | 3.8 | 1.5 | 0.6 | 3.6 | 0.6 | 0.2 | 1.7 | 1.8 | 0.8 | 3.8 | 1.5 | 0.8 | 2.7 | | Diabetes | 1.4 | 0.5 | 3.9 | 0.9 | 0.3 | 2.5 | 1.8 | 0.6 | 5.3 | 1.5 | 0.6 | 3.3 | 1.6 | 0.7 | 3.4 | | Derm | 1.1 | 0.6 | 1.9 | 1.5 | 1.0 | 2.3 | 1.2 | 0.8 | 1.9 | 1.6 | 1.0 | 2.3 | 2.5 | 1.9 | 3.3 | | CV | 0.0 | — | — | 3.6 | 0.5 | 25.4 | 2.2 | 0.5 | 9.0 | 1.8 | 0.3 | 9.8 | 4.3 | 1.3 | 14.1 | | Constitution | 1.4 | 0.6 | 3.1 | 1.3 | 0.7 | 2.5 | 2.3 | 1.2 | 4.2 | 1.7 | 1.0 | 3.0 | 2.8 | 1.8 | 4.6 | | CHF | 0.0 | — | — | 2.2 | 0.5 | 9.0 | 1.1 | 0.3 | 3.9 | 2.7 | 0.9 | 7.8 | 1.0 | 0.3 | 3.1 | | Breast cancer | 3.6 | 0.2 | 57.1 | 0.9 | 0.1 | 8.0 | NA | — | — | 1.8 | 0.3 | 9.8 | 1.8 | 0.3 | 9.8 | | Bleeding | 1.3 | 0.8 | 2.1 | 1.6 | 1.0 | 2.7 | 1.8 | 1.2 | 2.8 | 2.2 | 1.5 | 3.3 | 9.0 | 6.8 | 11.9 | | Autoimmune | 3.6 | 0.7 | 17.9 | 5.4 | 0.9 | 32.6 | Inf | — | — | 1.2 | 0.1 | 11.7 | 6.1 | 1.5 | 25.4 | | Arrhythmia | 0.7 | 0.2 | 3.3 | 0.0 | — | — | 0.3 | 0.0 | 2.0 | 0.7 | 0.2 | 3.3 | 3.6 | 1.4 | 9.1 |
|
|
| (b) |
| | Comorbidity group | Ratio ITP/non-ITP | | [diag +1[ | [+1 +2[ | [+2 +3[ | [+3 +4[ | [+4 +5[ |
| | Rate ratio | Lower CI | Upper CI | Rate ratio | Lower CI | Upper CI | Rate ratio | Lower CI | Upper CI | Rate ratio | Lower CI | Upper CI | Rate ratio | Lower CI | Upper CI | Ntotal ITP/ year |
| | CASMI | 1.9 | 0.7 | 5.6 | 0.9 | 0.2 | 4.1 | 2.0 | 0.5 | 8.0 | 1.0 | 0.1 | 9.3 | 4.4 | 0.9 | 21.6 | 4.1 | | PVD | 3.4 | 1.2 | 9.4 | 0.5 | 0.1 | 2.4 | 2.4 | 0.9 | 6.7 | 1.7 | 0.3 | 8.7 | 1.8 | 0.3 | 9.2 | 4.7 | | Heme | 3.8 | 2.2 | 6.6 | 2.4 | 1.3 | 4.5 | 5.9 | 3.0 | 11.6 | 2.0 | 0.8 | 5.2 | 0.8 | 0.2 | 2.7 | 16.4 | | Renal | Inf | — | — | Inf | — | — | 0.0 | — | — | 0.0 | — | — | 4.3 | 0.3 | 68.8 | 0.7 | | Pulmonary | 3.8 | 0.9 | 15.1 | 2.5 | 0.8 | 7.6 | 0.8 | 0.1 | 6.8 | 0.8 | 0.1 | 7.1 | 0.7 | 0.1 | 6.0 | 2.2 | | Oral | 3.6 | 1.9 | 6.8 | 3.1 | 1.5 | 6.4 | 0.5 | 0.1 | 2.2 | 1.8 | 0.6 | 5.0 | 1.0 | 0.3 | 3.6 | 9.5 | | Ophthalmologic | 2.8 | 1.4 | 5.7 | 0.9 | 0.3 | 2.8 | 1.1 | 0.3 | 3.9 | 0.9 | 0.3 | 3.1 | 1.3 | 0.4 | 4.1 | 6.5 | | Neurological | 2.4 | 0.9 | 6.2 | 0.2 | 0.0 | 1.7 | 1.8 | 0.5 | 5.7 | 2.7 | 0.8 | 9.7 | 0.6 | 0.1 | 5.0 | 3.0 | | Neoplasm | Inf | — | — | 0.0 | — | — | 8.0 | 0.7 | 87.8 | 0.0 | — | — | 0.0 | — | — | 1.0 | | Musculo-skeletal | 3.8 | 2.1 | 7.0 | 1.6 | 0.6 | 4.2 | 1.4 | 0.4 | 4.2 | 1.7 | 0.7 | 4.4 | 0.8 | 0.2 | 3.7 | 7.7 | | Mood disorder | 1.9 | 0.2 | 20.7 | 0.0 | — | — | 0.0 | — | — | 4.1 | 0.3 | 64.9 | Inf | — | — | 0.8 | | Infections | 1.9 | 1.2 | 3.1 | 1.7 | 0.9 | 3.0 | 2.2 | 1.1 | 4.2 | 2.0 | 0.8 | 4.5 | 0.5 | 0.1 | 2.0 | 13.5 | | Hypoglycemia | 5.7 | 0.9 | 33.8 | 2.0 | 0.2 | 21.8 | 2.6 | 0.4 | 15.8 | 0.0 | — | — | NA | — | — | 0.8 | | Hypersensitivity | 4.3 | 1.6 | 11.9 | 2.0 | 0.5 | 7.9 | 0.7 | 0.1 | 3.0 | 0.0 | — | — | 0.0 | — | — | 2.4 | | GU | 3.5 | 1.5 | 7.9 | 2.2 | 0.8 | 5.9 | 0.7 | 0.1 | 3.0 | 1.4 | 0.4 | 5.1 | 2.9 | 0.5 | 17.3 | 4.0 | | GI | 2.0 | 1.1 | 3.8 | 1.2 | 0.6 | 2.2 | 1.9 | 1.0 | 3.7 | 0.7 | 0.3 | 1.8 | 2.7 | 1.2 | 6.1 | 12.7 | | Edema | 2.4 | 1.4 | 3.9 | 0.6 | 0.2 | 1.6 | 0.2 | 0.1 | 0.9 | 0.9 | 0.3 | 2.3 | 0.7 | 0.2 | 2.3 | 8.4 | | Diabetes | 2.1 | 0.8 | 5.2 | 1.0 | 0.3 | 3.0 | 1.2 | 0.3 | 4.3 | 1.2 | 0.2 | 5.7 | 0.7 | 0.1 | 5.9 | 4.8 | | Derm | 2.5 | 1.8 | 3.6 | 1.0 | 0.7 | 1.6 | 1.6 | 1.0 | 2.6 | 1.3 | 0.8 | 2.4 | 0.9 | 0.4 | 1.9 | 30.1 | | CV | 1.9 | 0.7 | 5.0 | 0.7 | 0.1 | 2.9 | 2.2 | 0.7 | 6.6 | 0.0 | — | — | 1.2 | 0.3 | 6.0 | 2.8 | | Constitution | 2.3 | 1.6 | 3.5 | 1.1 | 0.7 | 1.9 | 1.8 | 1.0 | 3.3 | 1.6 | 0.8 | 3.1 | 1.2 | 0.5 | 3.1 | 17.6 | | CHF | 1.5 | 0.7 | 3.4 | 0.7 | 0.1 | 2.9 | 0.9 | 0.2 | 4.1 | 0.4 | 0.1 | 3.2 | 0.6 | 0.1 | 4.9 | 3.0 | | Breast cancer | 0.0 | — | — | 0.0 | — | — | 0.0 | — | — | Inf | — | — | 0.0 | — | — | 0.8 | | Bleeding | 2.9 | 2.0 | 4.1 | 3.9 | 2.6 | 5.7 | 1.7 | 1.0 | 3.0 | 0.7 | 0.3 | 1.7 | 2.3 | 1.3 | 4.2 | 40.1 | | Autoimmune | 15.4 | 1.7 | 137.5 | 2.0 | 0.4 | 11.0 | 12.2 | 1.3 | 117.2 | 2.1 | 0.2 | 23.3 | 0.0 | — | — | 2.3 | | Arrhythmia | 1.6 | 0.7 | 3.6 | 0.0 | — | — | 1.6 | 0.3 | 8.1 | 0.2 | 0.0 | 1.6 | 0.0 | — | — | 2.5 |
|
|
