Pathobiology of Anaplastic Large Cell Lymphoma

Table 1

Main translocation involving ALK recorded in anaplastic large cell lymphoma.

Chromosomal translocation	Partner gene	Fusion gene	Frequency (5)	ALK IHC detection
t(2;5)(p23;q35)	NPM1	NPM1/ALK	75–80	Cytoplasmic/nuclear
t(1;2)(q25;p23)	TMP3	TMP3/ALK	12–18	Cytoplasmic
inv(2)	ATIC	ATIC/ALK	2	Cytoplasmic
t(2;3)(p23;q21)	TGF	TGF/ALK	2	Cytoplasmic
t(2;17)(p23;q23)	CLTL	CLTL/ALK	2	Cytoplasmic
t(2;17)(p23;q25)	ALO17	ALO17/ALK	<1	Cytoplasmic
t(2;19)(p23;p13)	TPM4	TPM4/ALK	<1	Cytoplasmic
t(2;22)(p23;q11.2)	MYH9	MYH9/ALK	<1	Cytoplasmic
t(2;X)(p23;q11-12)	MSN	MSN/ALK	<1	Membranous

NPM1: nucleophosmin; ALK: anaplastic lymphoma kinase; TPM3: tropomyosin 3; ATIC: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; TGF: TRK-fused gene; CLTL: Clathrin heavy chainlike 1; ALO17: ALK lymphoma oligomerization partner on chromosome 17; TPM4: tropomyosin 4; MYH9: Nonmuscle myosin heavy chain; MSN: moesin; IHC: immunohistochemistry.