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Table 1: Diagnostic and therapeutic potenital of hepcidin in different forms of anemia.

Condition Expected hepcidin levels Other iron parameters Hepcidin therapy Iron deficiency anemia Low Low Tsat and ferritin Iron-refractory iron deficiency anemia High Low Tsat and ferritin Antagonist Iron-loading anemias Low (unless transfused) High Tsat and ferritin Agonist Anemia of inflammation High Low Tsat, normal-to-elevated ferritin Antagonist Mixed anemia (AI/IDA) Normal Low Tsat, low-to-normal ferritin Antagonist Chronic kidney disease High Variable Antagonist Erythropoietin resistance High Variable Antagonist

Tsat transferrin saturation.