Micro-RNA Expression and Function in Lymphomas

Table 2

Summary of up- and downregulated miRNA expression profiles in major types of lymphomas.

Lymphoma	Studies	Upregulated miRNAs	Downregulated miRNAs	Reference
Diffuse large B-cell lymphoma	DLBCL  (𝑛=59primary; 𝑛=27 cell lines)	See reference	See reference	[49]
	DLBCL ( 𝑛=98primary tumor; 𝑛=12 normal lymphocyte population)	hsa-miR-100, hsa-miR-10b, hsa-miR-125b, hsa-miR-143, hsa-miR-145, hsa-miR-155, hsa-miR-21, hsa-miR-34a, hsa-miR-451, hsa-miR-9	hsa-miR-150, hsa-miR-181a, hsa-miR-189, hsa-miR-223, hsa-miR-361, hsa-miR-363, hsa-miR-495, hsa-miR-584, hsa-miR-625, hsa-miR-768-5p	[56]
	DLBCL ( 𝑛=58) versus LN ( 𝑛=7)	hsa-miR-210, hsa-miR-155, hsa-miR-106a, hsa-miR-17-5p	hsa-miR-150, hsa-miR-145, hsa-miR-328, hsa-miR-139, hsa-miR-99a, hsa-miR-10a, hsa-miR-95, hsa-miR-149, hsa-miR-320, hsa-miR-151, hsa-miR-let-7e	[51]
Follicular lymphoma	FL( 𝑛=46) versus LN ( 𝑛=7)	hsa-miR-9, hsa-miR-9*, hsa-miR-301, hsa-miR-213, hsa-miR-330, hsa-miR-106a, hsa-miR-338, hsa-miR-155, hsa-miR-210	hsa-miR-320, hsa-miR-149, hsa-miR-139	[51]
Mantle cell lymphoma	MCL ( 𝑛=30)	hsa-miR-124a, hsa-miR-155, hsa-miR-328, hsa-miR-326, hsa-miR-302c, hsa-miR-345, hsa-miR-373*, and hsa-miR-210	hsa-miR-29a/b/c, hsa-miR-142-3p/5p, hsa-miR-150, and hsa-miR-15a/b	[54]
Burkitt lymphoma	BL ( 𝑛=10) versus CLL	hsa-miR-130b, hsa-miR-154, hsa-miR-155, hsa-miR-29b, hsa-miR-29c, hsa-miR-637, hsa-miR-658, hsa-miR-193a-5p, hsa-miR-886-5p, hsa-miR-768-5p, hsa-miR-101, hsa-miR-933, hsa-miR-371-5p, hsa-miR-675, hsa-miR-150, hsa-miR-874, hsa-miR-181a, hsa-miR-30c, ebv-hsa-miR-BHRF1-2, hsa-miR-628-3p		[58]
	cMyc +  BL  (𝑛=10) versus  cMyc − BL ( 𝑛=9)	hsa-miR-17-5p, hsa-miR-20a	hsa-miR-9*, hsa-miR-34b	[64]
Hodgkin lymphoma	cHL ( 𝑛=3, cell lines)	hsa-miR-17~92, hsa-miR-16, hsa-miR-15, hsa-miR-21, hsa-miR-24 and hsa-miR-155	hsa-miR-150	[39]
	HL/HRS cell versus GC B cells	hsa-miR-20a, hsa-miR-21, hsa-miR-9, hsa-miR-155, hsa-miR-16, hsa-miR-140, hsa-miR-18a, hsa-miR-30b, hsa-miR-30a-5p, hsa-miR-196a, hsa-miR-374, hsa-miR-186	hsa-miR-520a, hsa-miR-200a and hsa-miR-614	[36]
	cHL (primary, 𝑛=49)	hsa-miR-96, hsa-miR-128a, hsa-miR-128b		[38]
	HL cell lines ( 𝑛=3, L-428 & HD-MY-Z, L-1236)	hsa-miR-34a, hsa-miR-128b, hsa-miR-129, hsa-miR-200a	hsa-miR-122a, hsa-miR-154, hsa-miR-302d, hsa-miR-371	[38]
	cHL cell lines	hsa-miR-21, hsa-miR-27a, hsa-miR-147, hsa-miR-182, hsa-miR-183, hsa-miR-216	hsa-miR-126, hsa-miR-135a, hsa-miR-204	[38]
	EBV + versus EBV − cHL	hsa-miR-28, hsa-miR-130b, hsa-miR-132, hsa-miR-140, hsa-miR-330	hsa-miR-96, hsa-miR-128a, hsa-miR-128b, hsa-miR-129, hsa-miR-205	[38]
T-cell lymphoma	Sezary syndrome/SzS ( 𝑛=17)	hsa-miR-145, hsa-miR-574-5p, hsa-miR-200c, hsa-miR-199a*, hsa-miR-143, hsa-miR-214, hsa-miR-98, hsa-miR-518a-3p, hsa-miR-7	hsa-miR-342, hsa-miR-223, hsa-miR-150, hsa-miR-189(24*), hsa-miR-186, hsa-miR-423-3p, hsa-miR-92, hsa-miR-181a, hsa-miR-191, hsa-miR-376a	[59]
	Lymphocyte variant Hypereosinophilic syndrome/L-HES ( 𝑛=7)	Let-7b, hsa-miR-221, hsa-miR-222,	hsa-miR-26a, hsa-miR-31, hsa-miR-95, hsa-miR-99a, hsa-miR-100, hsa-miR-126, hsa-miR-130a, hsa-miR-135b, hsa-miR-135a, hsa-miR-151, hsa-miR-181a, hsa-miR-181b, hsa-miR-193a, hsa-miR-213, hsa-miR-215, hsa-miR-335, hsa-miR-340, hsa-miR-125a	[65]