Pathobiology of Hodgkin Lymphoma

Table 1

Hodgkin’s lymphoma (HL) classification schemes.

Jackson and Parker classification
Paragranuloma
Granuloma
Sarcoma
Lukes and Butler classification
Lymphocytic and/or histiocytic, nodular
Lymphocytic and/or histiocytic, diffuse
Nodular sclerosis
Mixed cellularity
Diffuse fibrosis
Reticular
Rye conference classification
Lymphocyte predominance
Nodular sclerosis
Mixed cellularity
Lymphocytic depletion
Revised European-American lymphoma (REAL) classification
Nodular lymphocyte predominance nodular/diffuse
Classic HL
Nodular sclerosis
Mixed cellularity
Lymphocyte depletion
Lymphocyte rich classic HL diffuse (provisional entity)
World Health Organisation scheme
Nodular lymphocyte predominant HL
Classic HL
Nodular sclerosis HL (grades 1 and 2)
Lymphocyte-rich classic HL*
Mixed cellularity HL
Lymphocyte-depleted HL
Unclassifiable classic HL

*This includes a nodular (common) and a diffuse (rare) form in contrast to the REAL classification.