Clinicopathologic features of major types of posttransplant lymphoproliferative disorders.
Early lesions (plasmacytic hyperplasia and infectious mononucleosis-like)
Polymorphic PTLD
Monomorphic PTLD
(i) Clinical features
(a) Age
Children and young adults
All age groups
All age groups
(b) Organ involved
Tonsils or lymph nodes
Lymph nodes, GIT, lung or allograft
Lymph node, any extranodal site, including bone marrow
(c) Regression
Usually regress either with minimal reduction of immunosuppressive drugs or spontaneously
Some cases regress, others progress
Very rare. Most cases progress rapidly
(ii) Histopathological features
(a) Tissue architecture
No or partial effacement
Nearly complete effacement
Complete effacement
(b) Nature of infiltrate
Comprised mainly of plasma cells and lymphoplasmacytoid cells in plasmacytic hyperplasia, and immunoblasts and plasmablasts in infectious mononucleosis-like lesion
Composed of a mixture of plasma cells, small lymphocytes, and large activated cells
Monotonous, similar to that of usual type B-cell NHL