Histocompatibility and Hematopoietic Transplantation in the Zebrafish

Figure 3

Survival of different zebrafish lines in response to radiation. Kaplan-Meier survival curves are shown for four different zebrafish strains after irradiation with a total dose of 25 Gy, delivered in two equal fractions of 12.5 Gy separated by 24 hours. Twenty one fish were irradiated in each group. CG1 is a clonal homozygous diploid fish line generated by parthenogenesis [21, 38]. UDA, UXA2, and UBA are inbred zebrafish lines derived from a single mating pair of AB parents [35]. Each line was named for the homozygous class I MHC gene at its chromosome 19 locus. The results demonstrate 100% mortality for the CG1 fish by day 22, and by day 37 for the UDA fish. In contrast, the UBA and UXA2 fish lines both had approximately 80% survival at 40 days after irradiation.