Through the Looking Glass: Visualizing Leukemia Growth, Migration, and Engraftment Using Fluorescent Transgenic Zebrafish
Figure 1
Fluorescently labeled Myc-induced T-ALLs from CG1-strain zebrafish engraft into nonirradiated CG1-strain recipients. (a)–(c) GFP-labeled T-ALLs were isolated from primary leukemic fish, and 1 × 103 FACS sorted GFP-labeled leukemia cells were transplanted into nonirradiated CG1-strain animals and scored for engraftment at 10, 20, and 30 days posttransplantation. (d)–(f) T-ALL transplant recipients that express Amcyan (d), dsRED (e), and zsYellow (f) under the rag2 promoter. Panels are merged images of fluorescent and brightfield photographs. Images were originally published in [23].
