The Role of BCL2 Family of Apoptosis Regulator Proteins in Acute and Chronic Leukemias

Figure 1

In this figure we show the two main pathways to apoptosis, and their interaction through the molecule BID, since death receptors activate the intrinsic pathway by activating BID. Either BAX or BAK are required for apoptosis, where they oligomerize in the mitochondrial outer membrane and induce the release of cytochrome c. DISC: death-inducing signaling complex, FADD: FAS-associated protein with death domain, TRAIL: TNF-related apoptosis-inducing ligand, APAF-1: apoptotic protease-activating factor, IAP: inhibitor of apoptosis proteins.