Association of Xmn I Polymorphism and Hemoglobin E Haplotypes on Postnatal Gamma Globin Gene Expression in Homozygous Hemoglobin E

Table 1

Summary of 8 different β globin haplotypes linked to Hb E alleles from 154 Hb E chromosomes.

Number	β-globin haplotypes								Xmn I	Total; 𝑁=154 (%)
	Annotations	ε HindII	G𝛾  HindIII	A𝛾  HindIII	5′β φHindII	3′β φHindII	5′β AvaII	3′β HinfI
(1)	(a) or III	−	+	−	+	+	+	−	+	93 (60.39)
(2)	(b) or V	+	−	−	−	−	+	−	−	37 (24.02)
(3)	(c) or IV	−	+	−	+	+	−	+	+	15 (9.74)
(4)	Y1	−	+	−	−	+	+	−	−	4 (2.60)
(5)	VIII	−	+	−	+	−	+	−	+	1 (0.65)
(6)	Y2	−	+	+	−	+	+	−	−	2 (1.30)
(7)	Th-1	−	−	−	−	−	+	−	−	1 (0.65)
(8)	Arab-Indian	+	+	−	+	+	+	−	+	1 (0.65)

(a), (b), and (c) were based on Antonarakis et al., 1982 [13]. III, V, IV, and VIII were based on Orkin et al., 1982 [19]. Y1 and Y2 were based on Yongvanit et al., 1989 [12]. Th-1 is a novel β globin haplotype found in this study. Arab-Indian haplotype was based on Nagel and Ranney, 1990 [20].