Murine Models of B-Cell Lymphomas: Promising Tools for Designing Cancer Therapies

Figure 1

Schematic representation of the major subtypes of B-cell lymphoma murine models. Murine models can be either spontaneous and develop in genetically engineered mice or can be induced by implantation of a tumor cell line. In this case, it is possible to inject cells in lymph nodes (nodal location) or outside of them (extranodal location). Immune sanctuaries such as the brain or the eyes provide information about that particular situation, but many other sites can be envisaged.