Murine Models of B-Cell Lymphomas: Promising Tools for Designing Cancer Therapies

Table 1

Spontaneous models of B-cell lymphoma. B-NHL: non-Hodgkin B-cell lymphoma; CLL: chronic lymphocytic leukemia; DLBCL: diffuse large B-cell lymphoma; DTG: double transgenic mice; n.d.: not determined.

Name	Lymphoma subtype/orgin	Strain (haplotype)	Major reference
B10 H-2^a H-4^bp/Wts	CLL	C57Bl/10 (H-2^b)	[2]
SL/KH	Pre-B lymphoma	SL/KH (H-2^11)	[3]
Eμ-N-myc	Indolent B-NHL	C57Bl/6 x DBA/2 (H-2^b/d)	[4]
NFS.V+	Marginal zone lymphoma	NFS.V+ (H-2^sq4)	[5]
NMRI/RFB-MuLV	n.d.	NMRI (H-2^q)	[6]
B6-l-MYC	Burkitt-like lymphoma	C57Bl/6 (H-2^b)	[7]
VavP-Bcl2	Follicular lymphoma	C57Bl/6 (H-2^b)	[8]
Lig4/p53 KO	Pro/Pre-B lymphoma	C57Bl/6 × sv129	[9]
Eμ-BRD2	DLBCL	FVB (H-2^q)	[10]
Bcl6 Knock in	Germinal center, DLBCL	C57Bl/6 × sv129	[11]
Bcl6/Myc transgenic	Post germinal center, DLBCL	C57Bl/6 × sv129	[11]
IL-14aTGxc-Myc TG (DTG)	Blastoid variant of mantle-cell lymphoma	C57Bl/6 (H-2^b)	[12]
Myc/BCR^HEL/HEL	Burkitt-like lymphoma	C57Bl/6 (H-2^b)	[13]
Eμ-myc	From follicular to DLBCL (time dependant)	C57Bl/6 × sv129	[14]
RzCD19Cre	NHL, hepatitis C induced	129/Sv (H-2^bc); BALB/c (H-2^d); C57Bl/6 (H-2^b)	[15]
UVB induced	Mature B-cell lymphoma	C57Bl/6 p53^+/− (H-2^b)	[16]