Bone Marrow and Peripheral Blood AML Cells Are Highly Sensitive to CNDAC, the Active Form of Sapacitabine

Table 1

Patient clinical characteristics.

Pt; ID number	FAB	WBC (Th/ul)	Hb; (g/dl)	Plt; (Th/ul)	Cytogenetics	FISH	Flt-3; ITD	Flt-3; TKD	NPM	%; Blasts PB	%; Blasts; BM
Normal range		4–10	13.5–17.5	150–450						−	≤5
005	M1	77	8.4	37	Trisomy 13	t/del(11)(q23) &; del(20)(q12)	ND	ND	−	88.9	98.5
038	M4Eo	27.06	8.5	57	Inv 16	ND	−	−	ND	ND	71.8
042	ND	43.03	8.9	89	Normal	ND	+	−	+	53	56.6
045	M2	93.75	10.2	50	Normal	ND	−	+	−	21.5	99
059	ND	90.78	7.2	35	Complex	ND	ND	ND	ND	90	90

FAB: French-American-British classification; WBC: white blood cell; Hb: hemoglobin level; Plt: platelet level; FISH: fluorescence in situ hybridization; Flt-3: FMS-like tyrosine kinase 3; ITD: internal tandem duplications; TKD: tyrosine kinase domain; NPM: nucleophosmin; ND: not determined.