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Advances in Hematology
Volume 2012 (2012), Article ID 784213, 6 pages
http://dx.doi.org/10.1155/2012/784213
Review Article

Nonengraftment Haploidentical Cellular Therapy for Hematologic Malignancies

Division of Hematology and Oncology, Rhode Island Hospital, The Warren Alpert Medical School, Providence, RI 02903, USA

Received 14 September 2011; Accepted 24 November 2011

Academic Editor: Thomas Kickler

Copyright © 2012 John L. Reagan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. H. J. Kolb, J. Mittermuller, C. Clemm et al., “Donor leukocyte transfusions for treatment of recurrent chronic myelogenous leukemia in marrow transplant patients,” Blood, vol. 76, no. 12, pp. 2462–2465, 1990. View at Scopus
  2. A. Fefer, M. A. Cheever, E. D. Thomas, et al., “Bone marrow transplantation for refractory acute leukemia in 34 patients with identical twins,” Blood, vol. 57, no. 3, pp. 421–430, 1981. View at Scopus
  3. P. L. Weiden, K. M. Sullivan, N. Flournoy, R. Storb, and E. D. Thomas, “Antileukemic effect of chronic graft-versus-host disease. Contribution to improved survival after allogeneic marrow transplantation,” The New England Journal of Medicine, vol. 304, no. 25, pp. 1529–1533, 1981. View at Scopus
  4. G. C. de Gast, P. G. Beatty, D. Amos et al., “Transfusion effect on graft-versus-host disease and leukemic relapse in HLA-matched bone marrow transplantation,” Transplantation Proceedings, vol. 19, no. 1, p. 2700, 1987. View at Scopus
  5. J. A. Sosman and P. M. Sondel, “The graft versus leukemia effect: possible mechanisms and clinical significance to the biologic therapy of leukemia,” Bone Marrow Transplantation, vol. 7, supplement 1, pp. 33–37, 1991. View at Scopus
  6. R. P. Gale and R. E. Champlin, “How does bone-marrow transplantation cure leukaemia?” The Lancet, vol. 2, no. 8393, pp. 28–30, 1984. View at Scopus
  7. C. S. Higano, M. Brixey, E. M. Bryant et al., “Durable complete remission of acute nonlymphocytic leukemia associated with discontinuation of immunosuppression following relapse after allogeneic bone marrow transplantation. A case report of a probable graft-versus-leukemia effect,” Transplantation, vol. 50, no. 1, pp. 175–177, 1990. View at Scopus
  8. R. H. Collins Jr., Z. R. Rogers, M. Bennett, V. Kumar, A. Nikein, and J. W. Fay, “Hematologic relapse of chronic myelogenous leukemia following allogeneic bone marrow transplantation: apparent graft-versus-leukemia effect following abrupt discontinuation of immunosuppression,” Bone Marrow Transplantation, vol. 10, no. 4, pp. 391–395, 1992. View at Scopus
  9. L. F. Odom, C. S. August, J. H. Githens, et al., “Remission of relapsed leukaemia during a graft-versus-host reaction. A “graft-versus-leukaemia reaction” in man?” The Lancet, vol. 2, no. 8089, pp. 537–540, 1978. View at Scopus
  10. H. J. Kolb, A. Schattenberg, J. M. Goldman et al., “Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients,” Blood, vol. 86, no. 5, pp. 2041–2050, 1995. View at Scopus
  11. C. K. Lee, M. de Magalhaes-Silverman, R. J. Hohl et al., “Prophylactic T cell infusion after T cell-depleted bone marrow transplantation in patients with refractory lymphoma,” Bone Marrow Transplantation, vol. 29, no. 7, pp. 615–620, 2002. View at Publisher · View at Google Scholar · View at Scopus
  12. H. S. Micklem, C. M. Clarke, E. P. Evans, and C. E. Ford, “Fate of chromosome-marked mouse bone marrow cells tranfused into normal syngeneic recipients,” Transplantation, vol. 6, no. 2, pp. 299–302, 1968. View at Scopus
  13. A. Takada, Y. Takada, and J. L. Ambrus, “Proliferation of donor spleen and bone-marrow cells in the spleens and bone marrows of unirradiated and irradiated adult mice,” Proceedings of the Society for Experimental Biology and Medicine, vol. 136, no. 1, pp. 222–226, 1971. View at Scopus
  14. G. Brecher, J. D. Ansell, H. S. Micklem, J. H. Tjio, and E. P. Cronkite, “Special proliferative sites are not needed for seeding and proliferation of transfused bone marrow cells in normal syngeneic mice,” Proceedings of the National Academy of Sciences of the United States of America, vol. 79, no. 16, pp. 5085–5087, 1982. View at Scopus
  15. D. F. Saxe, S. S. Boggs, and D. R. Boggs, “Transplantation of chromosomally marked syngeneic marrow cells into mice not subjected to hematopoietic stem cell depletion,” Experimental Hematology, vol. 12, no. 4, pp. 277–283, 1984. View at Scopus
  16. G. A. Colvin, D. Berz, M. Ramanathan et al., “Nonengraftment haploidentical cellular immunotherapy for refractory malignancies: tumorresponses without chimerism,” Biology of Blood and Marrow Transplantation, vol. 15, no. 4, pp. 421–431, 2009. View at Publisher · View at Google Scholar · View at PubMed
  17. M. Guo, K. X. Hu, C. L. Yu et al., “Infusion of HLA-mismatched peripheral blood stem cells improves the outcome of chemotherapy for acute myeloid leukemia in elderly patients,” Blood, vol. 117, no. 3, pp. 936–941, 2011. View at Publisher · View at Google Scholar · View at PubMed
  18. P. V. O'Donnell, L. Luznik, R. J. Jones et al., “Nonmyeloablative bone marrow transplantation from partially HLA-mismatched related donors using posttransplantation cyclophosphamide,” Biology of Blood and Marrow Transplantation, vol. 8, no. 7, pp. 377–386, 2002.
  19. B. R. Dey, S. McAfee, C. Colby et al., “Anti-tumour response despite loss of donor chimaerism in patients treated with non-myeloablative conditioning and allogeneic stem cell transplantation,” British Journal of Haematology, vol. 128, no. 3, pp. 351–359, 2005. View at Publisher · View at Google Scholar · View at PubMed
  20. F. M. Stewart, R. B. Crittenden, P. A. Lowry, S. P. White, and P. J. Quesenberry, “Long-term engraftment of normal and post-5-fluorouracil murine marrow into normal nonmyeloablated mice,” Blood, vol. 81, no. 10, pp. 2566–2571, 1993.
  21. H. S. Ramshaw, S. S. Rao, R. B. Crittenden, S. O. Peters, H. U. Weier, and P. J. Quesenberry, “Engraftment of bone marrow cells into normal unprepared hosts: effects of 5-fluorouracil and cell cycle status,” Blood, vol. 86, no. 3, pp. 924–929, 1995.
  22. H. S. Ramshaw, R. B. Crittenden, M. Dooner, S. O. Peters, S. S. Rao, and P. J. Quesenberry, “High levels of engraftment with a single infusion of bone marrow cells into normal unprepared mice,” Biology of Blood and Marrow Transplantation, vol. 1, no. 2, pp. 74–80, 1995.
  23. S. S. Rao, S. O. Peters, R. B. Crittenden, F. M. Stewart, H. S. Ramshaw, and P. J. Quesenberry, “Stem cell transplantation in the normal nonmyeloblasted host: relationship between cell dose, schedule, and engraftment,” Experimental Hematology, vol. 25, no. 2, pp. 114–121, 1997.
  24. G. A. Colvin, J. F. Lambert, M. Abedi et al., “Murine marrow cellularity and the concept of stem cell competition: geographic and quantitative determinants in stem cell biology,” Leukemia, vol. 18, no. 3, pp. 575–583, 2004. View at Publisher · View at Google Scholar · View at PubMed
  25. F. M. Stewart, S. Zhong, J. Wuu, C. C. Hsieh, S. K. Nilsson, and P. J. Quesenberry, “Lymphohematopoietic engraftment in minimally myeloablated hosts,” Blood, vol. 91, no. 10, pp. 3681–3687, 1998.
  26. F. M. Stewart, S. Zhong, J. F. Lambert et al., “Host marrow stem cell potential and engraftability at varying times after low-dose whole-body irradiation,” Blood, vol. 98, no. 4, pp. 1246–1251, 2001. View at Publisher · View at Google Scholar
  27. P. J. Quesenberry, S. Zhong, H. Wang, and M. Stewart, “Allogeneic chimerism with low-dose irradiation, antigen presensitization, and costimulator blockade in H-2 mismatched mice,” Blood, vol. 97, no. 2, pp. 557–564, 2001. View at Publisher · View at Google Scholar
  28. J. F. Lambert, G. A. Colvin, S. Zhong et al., “H2-mismatched transplantation with repetitive cell infusions and CD40 ligand antibody infusions without myeloablation,” British Journal of Haematology, vol. 119, no. 1, pp. 155–163, 2002. View at Publisher · View at Google Scholar
  29. K. K. Ballen, P. S. Becker, R. V. B. Emmons et al., “Low-dose total body irradiation followed by allogeneic lymphocyte infusion may induce remission in patients with refractory hematologic malignancy,” Blood, vol. 100, no. 2, pp. 442–450, 2002. View at Publisher · View at Google Scholar
  30. M. T. Rubio, Y. M. Kim, T. Sachs, M. Mapara, G. Zhao, and M. Sykes, “Antitumor effect of donor marrow graft rejection induced by recipient leukocyte infusions in mixed chimeras prepared with nonmyeloablative conditioning: critical role for recipient-derived IFN-γ,” Blood, vol. 102, no. 6, pp. 2300–2307, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  31. Y. Yang, H. Wang, H. Yu et al., “IFN-γ promotes graft-versus-leukemia effects without directly interacting with leukemia cells in mice after allogeneic hematopoietic cell transplantation,” Blood, vol. 118, no. 13, pp. 3721–3724, 2011. View at Publisher · View at Google Scholar · View at PubMed
  32. M. T. Rubio, T. I. Saito, K. Kattleman, G. Zhao, J. Buchli, and M. Sykes, “Mechanisms of the antitumor responses and host-versus-graft reactions induced by recipient leukocyte infusions in mixed chimeras prepared with nonmyeloablative conditioning: a critical role for recipient CD4+ T cells and recipient leukocyte infusion-derived IFN-gamma-producing CD8+ T cells,” Journal of Immunology, vol. 175, no. 2, pp. 665–676, 2005. View at Scopus
  33. T. I. Saito, H. W. Li, and M. Sykes, “Invariant NKT cells are required for antitumor responses induced by host-versus-graft responses,” Journal of Immunology, vol. 185, no. 4, pp. 2099–2105, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  34. E. S. Morris, K. P. A. MacDonald, and G. R. Hill, “Stem cell mobilization with G-CSF analogs: a rational approach to separate GVHD and GVL?” Blood, vol. 107, no. 9, pp. 3430–3435, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  35. M. di Ianni, F. Falzetti, A. Carotti et al., “Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation,” Blood, vol. 117, no. 14, pp. 3921–3928, 2011. View at Publisher · View at Google Scholar · View at PubMed
  36. J. Yu, X. Ren, F. Yan et al., “Alloreactive natural killer cells promote haploidentical hematopoietic stem cell transplantation by expansion of recipient-derived CD4+CD25+ regulatory T cells,” Transplant International, vol. 24, no. 2, pp. 201–212, 2011. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus