Table 1: Summary of the silencing of genes by knockdown methods affecting thrombocyte formation.

GeneFunctional evaluationPhenotypeReference

acvr1Laser thrombosisHemorrhagic/Prolonged TTO[36, 37]
ift122Laser thrombosisHemorrhagic/Prolonged TTO[36, 37]
poldip2Laser thrombosisHemorrhagic/Prolonged TTO[36, 37]
ripk5Laser thrombosisHemorrhagic/Prolonged TTO[36, 37]
mlck1aLaser thrombosisProlonged TTO[39]
bambiLaser thrombosisProlonged TTA/reduced thrombus surface area[11]
lrrc32Laser thrombosisProlonged TTA/Reduced TSA[11]
dcbld2Laser thrombosisIncreased TSA[11]
esamLaser thrombosisIncreased thrombus size[11]
prkca (PKC ) Laser thrombosisReduced TSA[40]
prkcb (PKC )Laser thrombosisReduced TSA[40]
itga2b (CD41)Laser thrombosis/thrombocyte aggregation assaysReduced TSA/Prolonged TTO/no aggregation of thrombocytes[11, 41]
scl Thrombocyte formationReduction in GFP+ cells in CD41-GFP transgenic zebrafish line[48]
c-mplThrombocyte formationReduction in GFP+ cells in CD41-GFP transgenic zebrafish line[48]
runx1Whole mount in situ hybridization/immunostainingAccumulation of hematopoietic progenitors[52]
miR-126/c-mybThrombocyte formationDecrease in CD41 : EGFP+ thrombocytes in a double transgenic reporter line Tg (cd41 :  EGFP)  : Tg (gata1 : dsRed)[55]
fog1Thrombocyte formationFailure to generate eGFP+ cells in CD41-GFP transgenic zebrafish line[56]
mastlThrombocyte formationReduction in GFP+ cells in CD41-GFP transgenic zebrafish line[58]
march2Thrombocyte formationReduction in GFP+ cells in CD41-GFP transgenic zebrafish line[59]
maxThrombocyte formationReduction in GFP+ cells in CD41-GFP transgenic zebrafish line[59]
smoxThrombocyte formationReduction in GFP+ cells in CD41-GFP transgenic zebrafish line[59]
pttg11pThrombocyte formationReduction in GFP+ cells in CD41-GFP transgenic zebrafish line[59]
emilin1Thrombocyte formationReduction in GFP+ cells in CD41-GFP transgenic zebrafish line[59]
sufuThrombocyte formationReduction in GFP+ cells in CD41-GFP transgenic zebrafish line[59]
arhgef3Thrombocyte formationAbsence of GFP+ cells in CD41-GFP transgenic zebrafish line[60]
ak3Thrombocyte formationAbsence of GFP+ cells in CD41-GFP transgenic zebrafish line[60]
rnf45Thrombocyte formationAbsence of GFP+ cells in CD41-GFP transgenic zebrafish line[60]
jmjd1cThrombocyte formationAbsence of GFP+ cells in CD41-GFP transgenic zebrafish line[60]
tpmaThrombocyte formationAbsence of GFP+ cells in CD41-GFP transgenic zebrafish line[60]
nbeal2Thrombocyte formationAbrogation of thrombocyte formation[61]
rgs18Thrombocyte formationThrombocytopenia[62]