Synergistic Effect of Anemia and Red Blood Cells Transfusion on Inflammation and Lung Injury

Figure 1

Effect of blood loss on systemic inflammation response and lung endothelial permeability. (a) Hct, (b) plasma IL-6, (c) plasma KC, and (d) plasma S1P were measured at baseline (time = 0; 𝑛=6) or at 24 (𝑛=3) or 48 hours (𝑛=3) after major blood loss (0.02 mL/gm). (e) Lung permeability was measured in mice that had not undergone blood loss (time = 0; 𝑛=3) or at 48 hours after major blood loss (𝑛=3) by quantifying accumulation of IV injected EBD into the lung. Results were analyzed by one-way ANOVA (Bonferroni correction) *𝑃<0.05 versus time = 0.

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