924042.fig.001a
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924042.fig.001b
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Figure 1: Effect of blood loss on systemic inflammation response and lung endothelial permeability. (a) Hct, (b) plasma IL-6, (c) plasma KC, and (d) plasma S1P were measured at baseline (time = 0; ) or at 24 ( ) or 48 hours ( ) after major blood loss (0.02 mL/gm). (e) Lung permeability was measured in mice that had not undergone blood loss (time = 0; ) or at 48 hours after major blood loss ( ) by quantifying accumulation of IV injected EBD into the lung. Results were analyzed by one-way ANOVA (Bonferroni correction) * versus time = 0.