| | Analyte | Units | Range* | D1**
| D2**
| D3**
| D4**
| ANOVA |
| | Urea | mmol/L | 2.3, 75 | 4.24 (0.21) | 4.17 (0.20) | 4.13 (0.19) | 4.07 (0.22) | NS | | Creatinine | mol/L | 47, 108 | 72.0 (2.80) | 75.2 (2.91) | 76.7 (3.03) | 75.5 (2.88) | NS | | Bicarbonate | mmol/L | 22.0, 28.5 | 25.3 (0.31) | 18.8 (0.39) | 16.9 (0.25) | 16.9 (0.30) | d2, d3, d4 | | Glucose | mmol/L | 3.5, 9.0 | 4.97 (0.19) | 5.06 (0.19) | 5.16 (0.22) | 5.21 (0.31) | NS | | Sodium | mmol/L | 135, 144 | 140 (0.40) | 143 (0.49) | 147 (0.53) | 148 (0.78) | d3, d4 | | Potassium | mmol/L | 3.4, 5.0 | 4.1 (0.05) | 4.2 (0.05) | 4.4 (0.07) | 4.4 (0.08) | d3, d4 | | Chloride | mmol/L | 101, 107 | 104 (0.32) | 105 (0.40) | 107 (0.37) | 109 (0.51) | d3, d4 | | Total Protein | g/L | 60, 80 | 71.0 (0.74) | 72.2 (0.74) | 73.6 (0.97) | 73.4 (1.14) | NS | | Albumin | g/L | 34, 44 | 38.8 (0.45) | 39.1 (0.49) | 40.7 (0.53) | 41.4 (0.63) | d3, d4 | | Total Bilirubin | µmol/L | 4.4, 23.5 | 9.69 (0.89) | 8.95 (0.81) | 8.79 (0.79) | 8.26 (1.05) | NS | | ALP | U/L | 39, 331 | 73.4 (10.7) | 75.9 (11.3) | 81.8 (12.9) | 95.8 (19.6) | NS | | ALT | U/L | 7, 36 | 16.4 (1.22) | 16.1 (1.12) | 15.3 (1.24) | 16.0 (1.60) | NS | | AST | U/L | 10, 26 | 15.6 (0.71) | 16.2 (0.70) | 16.7 (0.85) | 18.1 (1.11) | NS | | Cholesterol | mmol/L | 3.17, 6.27 | 4.84 (0.14) | 4.91 (0.14) | 4.99 (0.16) | 4.89 (0.20) | NS | | HDL | mmol/L | 0.79, 2.75 | 1.47 (0.06) | 1.46 (0.06) | 1.51 (0.07) | 1.52 (0.10) | NS | | Triglycerides | mmol/L | 0.42, 2.88 | 1.18 (0.10) | 1.22 (0.10) | 1.26 (0.11) | 1.33 (0.16) | NS | | TSH | mU/L | 0.487, 6.20 | 1.889 (0.21) | 1.893 (0.21) | 2.010 (0.24) | 2.360 (0.34) | NS | | fT4 | pmol/L | 8.7, 14.6 | 11.3 (0.24) | 10.9 (0.24) | 11.1 (0.26) | 11.2 (0.36) | NS | | CK-MB | g/L | 0.88, 4.82 | 1.80 (0.15) | 1.88 (0.14) | 1.65 (0.14) | 1.61 (0.21) | NS | | NT-proBNP | pg/mL | 5.0, 100.6 | 35.9 (4.98) | 37.3 (4.97) | 37.9 (5.28) | 47.5 (7.00) | NS |
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