Review Article

The Genetic Architecture of Multiple Myeloma

Figure 2

Overexpression of cyclin D genes influence cell cycle progression at the G 1/S transition point in myeloma. Increased cyclin D gene expression through hyperdiploid or nonhyperdiploid events in myeloma facilitates activation of a cyclin-dependent kinase (CDK 4 or 6). The respective CDK then phosphorylates Rb (retinoblastoma protein), which subsequently resides from its role inhibiting E2F transcription factors allowing these to facilitate cell cycle progression at the G1/S transition. G1: Gap-1 phase; S: synthesis phase; G2: Gap-2 phase; M: mitosis; P: phosphate group.
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