Thalassemia and Hemoglobin E in Southern Thai Blood Donors

Table 3

Hematological findings of normal and different types of thalassemia and Hb E.

Group (𝑛)	Hb (g/L)	MCV (fL)	MCH (pg)	Hb A2/E (%)
I. Normal and heterozygous 𝛼-thalassemia 2 (𝑛=101)	141±13.4	84.9±4.31	30.0±1.68	—
II. Homozygous 𝛼-thalassemia 2 and heterozygous 𝛼-thalassemia 1 (𝑛=4)	129±10.5	65.1±2.44	21.4±0.90	2.9±0.25
III. Heterozygous 𝛽-thalassemia without 𝛼-thalassemia (𝑛=1)	139	62.2	20.0	5.0
IV. Heterozygous Hb E without 𝛼-thalassemia (𝑛=6)	134±9.6	75.1±3.39	25.2±1.16	26.2±0.58
V. Double heterozygotes for Hb E/𝛼-thalassemia 1 (𝑛=2)	123±6.4	67.5±1.84	21.8±0.57	19.3±0.64
VI. Homozygous Hb E without 𝛼-thalassemia (𝑛=1)	127	61.6	19.7	74.5
VII. Homozygous Hb E with heterozygous 𝛼-thalassemia 2 (𝑛=1)	139	67.6	22.0	75.4
𝑃 value*	0.05	<0.001	<0.001	<0.001

Hematological data are expressed either as mean ± standard deviation (SD) or raw data where appropriate (𝑛=1, groups III, VI, and VII).
Hb: hemoglobin; g/L: gram per liter; MCV: mean corpuscular volume; fL: femtoliter; MCH: mean corpuscular hemoglobin; pg: picogram.
^∗𝑃 value was calculated by using the nonparametric Kruskal-Wallis test (groups I, II, IV, and V were compared).