Real-World Assessment of Clinical Outcomes in Patients with Lower-Risk Myelofibrosis Receiving Treatment with Ruxolitinib

Table 2

Patient characteristics.

	All patients		IPSS category
			Low risk		Intermediate-1 risk
		%		%		%
Total patients	108	100.00	25	100.00	83	100.00
Age
≤65 years	91	84.26	25	100.00	66	79.52
>65 years	17	15.74	0	0.00	17	20.48
Sex
Male	72	66.67	15	60.00	57	68.67
Female	36	33.33	10	40.00	26	31.33
Race or ethnicity
White	79	73.15	21	84.00	58	69.88
Black	16	14.81	2	8.00	14	16.87
Hispanic	10	9.26	0	0.00	10	12.05
Other	2	1.85	1	4.00	1	1.20
Do not know	1	0.93	1	4.00	0	0.00
Primary insurance type at ruxolitinib initiation
Commercial	43	39.81	10	40.00	33	39.76
Medicare	47	43.52	9	36.00	38	45.78
Medicaid	9	8.33	2	8.00	7	8.43
Uninsured	0	0.00	0	0.00	0	0.00
Other	2	1.85	0	0.00	2	2.41
Do not know	7	6.48	4	16.00	3	3.61
MF type at diagnosis
Primary MF	88	81.48	20	80.00	68	81.93
Postpolycythemia vera MF	10	9.26	3	12.00	7	8.43
Postessential thrombocythemia MF	9	8.33	2	8.00	7	8.43
Do not know	1	0.93	0	0.00	1	1.20
JAK2 V617F mutation test result
Positive	74	68.52	14	56.00	60	72.29
Negative	21	19.44	7	28.00	14	16.87
Test not done	3	2.78	1	4.00	2	2.41
Do not know	10	9.26	3	12.00	7	8.43
Charlson comorbidities at ruxolitinib initiation
Hypertension	35	32.41	6	24.00	29	34.94
Diabetes (overall)	17	15.74	2	8.00	15	18.07
Diabetes (without end organ damage)	15	13.89	1	4.00	14	16.87
Chronic pulmonary disease	9	8.33	1	4.00	8	9.64
Liver disease (overall)	7	6.48	1	4.00	6	7.23
Depression	7	6.48	0	0.00	7	8.43
Mild liver disease	6	5.56	1	4.00	5	6.02
Cerebrovascular disease	5	4.63	1	4.00	4	4.82
Connective tissue disease	4	3.7	1	4.00	3	3.61
Dementia	3	2.78	0	0.00	3	3.61
Malignant solid tumor	3	2.78	1	4.00	2	2.41
HIV/AIDS	2	1.85	0	0.00	2	2.41
Hemiplegia	2	1.85	0	0.00	2	2.41
Myocardial infarction	2	1.85	0	0.00	2	2.41
Diabetes (with end organ damage)	2	1.85	1	4.00	1	1.20
Malignant lymphoma	1	0.93	0	0.00	1	1.20
Moderate or severe liver disease	1	0.93	0	0.00	1	1.20
Peripheral vascular disease	1	0.93	0	0.00	1	1.20
Ulcer disease	1	0.93	1	4.00	0	0.00
Congestive heart failure	0	0	0	0.00	0	0.00
None of these	36	33.33	11	44.0	25	30.12
Other	0	0.00	0	0.0	0	0.00
Do not know	8	7.41	4	16.0	4	4.82
Ruxolitinib doses utilized
Starting median daily dose, mg (min, max)	30 (2, 56)		30 (4, 56)		30 (2, 50)
Dose range observed over entire treatment duration, (min, max)	2, 60		4, 60		2, 50
Still on ruxolitinib at last available follow-up?
Yes	87	80.60	23	92.00	64	77.10
No	15	13.90	2	8.00	13	15.70
Do not know	6	5.60	0	0.00	6	7.20

IPSS, International Prognostic Scoring System; JAK2, Janus kinase 2; MF, myelofibrosis.