Review Article
Combined Bone Marrow and Kidney Transplantation for the Induction of Specific Tolerance
| Center | MGH | MGH | MGH | Stanford | Northwestern |
| Transplant type | HLA-matched related donor KdBMT for HM | Haploidentical donor KdBMT for HM | Haploidentical donor KdBMT for ESRD without malignancy | HLA-matched and haploidentical related and unrelated donor KdBMT for ESRD without malignancy | Haploidentical/mismatched related and unrelated donor KdBMT for ESRD without malignancy |
| Chimerism goal | FDC | FDC | Transient mixed | Sustained mixed | FDC |
| Results | Removal of IS in 5 of 10 patients (50%) Sustained antitumor responses in 30% | 3 of 4 patients in remission, two likely tolerant | 4 of 10 (40%) with sustained tolerance | Removal of IS in 44% (HLA-matched) 0% sustained tolerance (haploidentical or unrelated donor) | Removal of IS in 5 of 8 (63%) patients |
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KdBMT: kidney and bone marrow transplant; HM: hematologic malignancy; FDC: full donor chimerism; IS: immunosuppression.
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