Research Article
Impact of Age on Outcomes in Hospitalized Patients with Hereditary Hemorrhagic Telangiectasia
Table 2
Complication rates and procedures in different age groups.
| | | Age groups |
| | Complication | <18 | 18–50 | 51–65 | >65 | value | | (%) | 458 | 1938 | 3097 | 4800 | | | Hemorrhagic | 70 (15.3) | 1032 (53.3) | 2085 (67.3) | 3268 (68.1) | <.0001 | | Anemia | 53 (11.6) | 867 (44.7) | 1789 (57.8) | 2775 (57.8) | <.0001 | | Epistaxis | 11 (2.4) | 265 (13.7) | 592 (19.1) | 801 (16.7) | <.0001 | | GI bleed | 19 (4.2) | 192 (9.9) | 328 (10.6) | 572 (11.9) | <.0001 | | Hematemesis | 3 (0.7) | 26 (1.3) | 36 (1.2) | 43 (0.9) | .29 | | Hemoptysis | 3 (0.7) | 4 (0.2) | 12 (0.4) | 31 (0.7) | .09 | | Cardiovascular | 51 (11.1) | 329 (17.0) | 1075 (24.7) | 2761 (57.5) | <.0001 | | CHF | 3 (0.7) | 94 (4.9) | 467 (15.1) | 1488 (31.0) | <.0001 | | Coronary artery disease | 0 (0.0) | 81 (4.2) | 371 (12.0) | 1266 (26.4) | <.0001 | | Atrial fibrillation | 0 (0.0) | 31 (1.6) | 298 (9.6) | 1094 (22.8) | <.0001 | | Pulmonary hypertension | 44 (9.6) | 161 (8.3) | 295 (9.5) | 450 (9.4) | .48 | | MI | 0 (0.0) | 11 (0.6) | 52 (1.7) | 108 (2.3) | <.0001 | | Pulmonary embolism | 0 (0.0) | 25 (1.3) | 43 (1.4) | 49 (1.0) | .046 | | DVT | 0 (0.0) | 16 (0.8) | 42 (1.4) | 50 (1.0) | .04 | | Pulmonary AVM | 8 (1.8) | 20 (1.0) | 33 (1.1) | 21 (0.4) | .0006 | | Vfib/cardiac arrest | 0 (0.0) | 3 (0.2) | 12 (0.4) | 17 (0.4) | .28 | | Neurologic | 77 (16.8) | 453 (23.4) | 385 (12.4) | 361 (7.5) | <.0001 | | Seizure | 38 (8.3) | 211 (10.9) | 207 (6.7) | 172 (3.5) | <.0001 | | Headache | 25 (5.5) | 186 (9.6) | 99 (3.2) | 53 (1.1) | <.0001 | | Stroke | 2 (0.4) | 39 (2.0) | 56 (1.8) | 138 (2.9) | .0004 | | BAVM | 20 (4.4) | 37 (1.9) | 22 (0.7) | 9 (0.2) | <.0001 | | TIA | 0 (0.0) | 9 (0.5) | 20 (0.7) | 40 (0.8) | .09 | | Cerebral abscess | 0 (0.0) | 23 (1.2) | 24 (0.8) | 8 (0.2) | <.0001 | | ICH | 1 (0.2) | 16 (0.8) | 8 (0.3) | 6 (0.1) | <.0001 | | SAH | 2 (0.4) | 12 (0.6) | 7 (0.2) | 0 (0.0) | <.0001 | | Cerebral aneurysm | 1 (0.2) | 10 (0.5) | 9 (0.3) | 11 (0.2) | .27 | | Spinal vascular malformation | 1 (0.2) | 4 (0.2) | 0 (0.0) | 0 (0.0) | .0009 | | Hepatobiliary complications | 5 (1.1) | 113 (5.8) | 265 (8.6) | 277 (5.8) | <.0001 | | Cirrhosis | 2 (0.4) | 67 (3.5) | 201 (6.5) | 178 (3.7) | <.0001 | | Biliary complications | 2 (0.4) | 32 (1.7) | 54 (1.7) | 81 (1.7) | .22 | | Portal hypertension | 1 (0.2) | 20 (1.0) | 61 (2.0) | 51 (1.1) | .0004 | | Chronic liver failure | 1 (0.2) | 10 (0.5) | 16 (0.5) | 19 (0.4) | .71 | | Jaundice | 0 (0.0) | 4 (0.2) | 9 (0.3) | 7 (0.2) | .39 | | Acute liver failure | 0 (0.0) | 5 (0.3) | 1 (0.0) | 6 (0.1) | .12 | | Procedures | 97 (21.2) | 875 (45.2) | 1768 (57.1) | 2617 (54.5) | <.0001 | | Transfusion | 59 (12.9) | 586 (30.2) | 1343 (43.4) | 1920 (40.0) | <.0001 | | Upper endoscopy | 15 (3.3) | 184 (9.5) | 286 (9.2) | 496 (10.3) | <.0001 | | Lower endoscopy | 8 (1.8) | 80 (4.1) | 124 (4.0) | 244 (5.1) | .002 | | Surgical ligation for epistaxis | 5 (1.1) | 62 (3.2) | 141 (4.6) | 196 (4.1) | .001 | | Nasal packing | 2 (0.4) | 31 (1.6) | 102 (3.3) | 240 (5.0) | <.0001 | | Endovascular treatment of epistaxis | 16 (3.5) | 48 (2.5) | 51 (1.7) | 36 (0.8) | <.0001 | | Cardiac catheterization | 2 (0.4) | 40 (2.1) | 95 (3.1) | 138 (2.9) | .003 | | Hemodialysis | 0 (0.0) | 35 (1.8) | 30 (1.0) | 67 (1.4) | .005 | | IVC filter | 0 (0.0) | 19 (1.0) | 34 (1.1) | 39 (0.8) | .11 | | CPR | 1 (0.2) | 7 (0.4) | 5 (0.2) | 7 (0.2) | .31 |
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GI = gastrointestinal; CHF = congestive heart failure; MI = myocardial infarction; DVT = deep vein thrombosis; AVM = arteriovenous malformation; Vfib = ventricular fibrillation; BAVM = brain arteriovenous malformation; TIA = transient ischemic attack; ICH = intracranial hemorrhage; SAH = subarachnoid hemorrhage; IVC = inferior vena cava; CPR = cardiopulmonary resuscitation.
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