Ribavirin at the Era of Novel Direct Antiviral Agents for the Treatment of Hepatitis C Virus Infection: Relevance of Pharmacological Monitoring

Table 4

Mean ribavirin plasma concentration.

Patients; ()	Dialysis patients; (		Moderate or severe renal insufficiency; ()
Treatment response	Responder	Nonresponder	Responder	Nonresponder
W4
EVR	1.47	0.91	2.7	2.36
SVR	1.26 (RR: 0.56)		2.86 (RR: 2.54)
W8
EVR	1.48	1.22	2.5	2.15
SVR	1.38 (RR: 0.8)		2.76 (RR: 2.31)
W12
EVR	1.65	1.42	2.79	3.07
SVR	1.74 (RR: 1.48)		3.22 (RR: 2.43)