Beta2-Adrenergic Receptor Gene Polymorphisms in Egyptian Patients with Acute Myocardial Infarction
Table 6
Disease characteristics of patients according to ADRB2 haplotypes ().
Characteristics
Arg16/Gln27
value
Gly16/Gln27
value
Gly16/Glu27
value
Positive
Negative
Positive
Negative
Positive
Negative
Total number
40 (59)
28 (41)
29 (42.7)
39 (57.3)
34 (50)
34 (50)
Risk factors for CVD
Age at diagnosis
53 ± 7.9
55 ± 6.6
0.355
53.8 ± 7.8
53.3 ± 7.1
0.582
54.3 ± 7.1
52.7 ± 7.7
0.443
Male gender, %
29 (64.4)
16 (35.6)
0.188
16 (35.6)
29 (64.4)
0.098
25 (55.6)
20 (44.4)
0.200
Smokers, %
24 (64.9)
13 (35.1)
0.269
12 (38.7)
19 (61.3)
0.548
15 (48.4)
16 (51.6)
0.808
FH of CVD, %
17 (51.5)
16 (48.5)
0.234
13 (39.4)
20 (60.6)
0.598
20 (60.6)
13 (39.4)
0.089
Hypertension, %
30 (62.5)
18 (37.5)
0.340
24 (50.0)
24 (50.0)
0.058
16 (33.3)
32 (66.7)
<0.001*
DM, %
12 (37.5)
20 (62.5)
0.001*
17 (53.1)
15 (46.9)
0.100
18 (56.3)
14 (43.7)
0.331
BMI, Kg/m2
30.2 ± 4
28.5 ± 3
0.121
29.1 ± 3
29.7 ± 4
0.955
28.9 ± 4
30.0 ± 3
0.090
Lipid profile
Hyperlipidemia, %
38 (61.3)
24 (38.7)
0.184
25 (40.3)
37 (59.7)
0.213
31 (50.0)
31 (50.0)
1.000
Total cholesterol, mg/dL
206 ± 36
188 ± 42
0.030*
192 ± 44
204 ± 36
0.070
198 ± 39
199 ± 41
0.731
Total triglyceride, mg/dL
207 ± 68
196 ± 54
0.945
192 ± 59
210 ± 65
0.330
205 ± 71
199 ± 56
0.864
HDL-C, mg/dL
38.5 ± 6.3
37.1 ± 8
0.170
38 ± 8.7
38.2 ± 6
0.471
38.0 ± 7.1
37.9 ± 7
0.917
LDL-C, mg/dL
126 ± 36
112 ± 46
0.061
115 ± 48
124 ± 34
0.133
119 ± 39
121 ± 43
0.722
VLDL-C, mg/dL
41.4 ± 13
39.2 ± 11
0.945
38.4 ± 11
42.1 ± 13
0.330
41.1 ± 14
39.9 ± 11
0.864
Cardiac enzymes
CK, ng/mL
1530 ± 1583
1912 ± 2149
0.842
1978 ± 2359
1471 ± 1305
0.995
1554 ± 1554
1821 ± 2088
0.581
CK-MB. ng/mL
337 ± 351
294 ± 402
0.159
327 ± 405
314 ± 347
0.660
345 ± 418
293 ± 320
0.835
LDH, IU/L
1442 ± 1051
1733 ± 1437
0.852
1655 ± 1662
1493 ± 768
0.267
1350 ± 801
1774 ± 1517
0.358
Values are shown as mean ± standard deviation or number (percentage). CVD: cardiovascular disease; FH: family history; DM: diabetes mellitus; BMI: body mass index; FBS: fasting blood sugar; HDL-C: high density lipoprotein cholesterol; LDL-C: low density lipoprotein cholesterol; CK: total creatine kinase; CK-MB: creatine kinase isoenzyme MB fraction; LDH: lactate dehydrogenase. Two-sided chi-square and Mann-Whitney tests were used. *Statistically significant at < 0.05.
