Research Article

Effects of Atorvastatin on Oxidative Stress Biomarkers and Mitochondrial Morphofunctionality in Hyperfibrinogenemia-Induced Atherogenesis

Table 1

Mitochondrial quantifications in the smooth muscle of the thoracic aorta of rats with atherogenesis induced by hyperfibrinogenemia and treated with atorvastatin.

MeasurementsCtr (A)Ctr + Ator (B)AI (C)AI + Ator

Total number of mitochondria*54533741
Mean number of
mitochondria*
9 ± 0.308.8 ± 0.256.4 ± 0.977.5 ± 0.75
Mean area of
mitochondria
465.61 ± 28.06 m2458.88 ± 27.09 m2792.068 ± 97.70 m2667 ± 56.73 m2
Alteration
 Grade 187.25%91.32%5.4%42.5%
 Grade 212.75%8.68%24.32%39.15%
 Grade 30%0%70.27%18.75%

Total area measured 1986 m2. ( for all groups.)