Research Article
Calcium Carbonate versus Sevelamer Hydrochloride as Phosphate Binders after Long-Term Disease Progression in 5/6 Nephrectomized Rats
Table 1
Characteristics and laboratory findings in the study groups.
| | Sham | Ca-Sham | Seve-Sham | NX | Ca-NX | Seve-NX |
| Weight of kidney tissue removed | | | | 6.3 ± 0.1 | 6.2 ± 0.1 | 6.2 ± 0.2 | in the 5/6 nephrectomy (g/kg) | | | | Body weight (g) | | | | | | | Week 15 | 454 ± 11 | 452 ± 8 | 452 ± 7 | 438 ± 7 | 447 ± 11 | 442 ± 16 | Week 24 | 495 ± 13 | 474 ± 8 | 504 ± 12 | 476 ± 11 | 467 ± 16 | 459 ± 17 | Systolic blood pressure (mmHg) | | | | | | | Week 15 | 125 ± 10 | 123 ± 9 | 118 ± 5 | 127 ± 6 | 133 ± 7 | 132 ± 5 | Week 24 | 135 ± 4 | 136 ± 4 | 144 ± 7 | 169 ± 4* | 151 ± 5*† | 167 ± 9* | Creatinine (mol/L) | | | | | | | Week 15 | n.d. | n.d. | n.d. | 88.2 ± 5.3 | 87.3 ± 7.1 | 88.6 ± 5.5 | Week 24 | 49.6 ± 2.6 | 52.5 ± 1.9 | 53.2 ± 2.5 | 84.5 ± 7.6* | 128.8 ± 25.7*† | 161.7 ± 33.2*† | Sampling at close of the study (week 24) | | | | | | | pH | 7.40 ± 0.05 | 7.43 ± 0.03 | 7.22 ± 0.07*# | 7.41 ± 0.03 | 7.34 ± 0.05 | 7.21 ± 0.04*† | Sodium (mmol/L) | 136.0 ± 0.5 | 135.7 ± 0.3 | 136.1 ± 0.5 | 136.7 ± 0.5 | 135.4 ± 0.6 | 138.2 ± 1.2 | Potassium (mmol/L) | 3.92 ± 0.09 | 3.79 ± 0.21 | 3.90 ± 0.07 | 4.49 ± 0.15* | 4.88 ± 0.24* | 5.12 ± 0.23*† | Hemoglobin (g/L) | 177.3 ± 2.1 | 175.0 ± 2.2 | 182.0 ± 1.3 | 158.3 ± 4.6* | 157.3 ± 3.9* | 143.9 ± 8.8*†‡ | Heart wt/body wt (g/kg) | 3.48 ± 0.07 | 3.40 ± 0.06 | 3.92 ± 0.44 | 4.53 ± 0.48* | 4.26 ± 0.23 | 5.45 ± 0.51*‡ | Ca-Pi product (mmol2/L2) | 3.03 ± 0.14 | 2.05 ± 0.11* | 3.22 ± 0.17# | 4.10 ± 0.49* | 2.49 ± 0.26*† | 5.24 ± 0.53*‡ | Urine sampling at close of the study (week 24) | | | | | | | Protein (mg/24 h) | 70.8 ± 8.0 | 74.2 ± 10.0 | 111.2 ± 26.8 | 242.3 ± 31.6* | 260.5 ± 46.4* | 285.2 ± 38.8* |
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Mean ± SEM; = 10–20 (see Figure 1); n.d. = not determined. versus Sham, versus NX, Ca-NX versus Seve-NX, and Ca-Sham versus Seve-Sham.
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