Rho-GTPase Signalling in the Pathogenesis of Nephrotic Syndrome

Figure 1

Summary of functional and pathogenic consequences of Rho-GTPase activity imbalances within podocytes. The activities of RhoA, Rac1, and Cdc42 within podocytes must remain under tight regulatory control in order to maintain foot process architecture and cellular function to prevent the occurrence of proteinuric disease.