Hematopoietic Stem Cell Function in a Murine Model of Sickle Cell Disease
Figure 1
Hemoglobin and hematology profile of Berkeley sickle mice. Hemoglobin electrophoresis of RBC from C57BL/6, H-2, H-1, and homozygous sickle mice. C57BL/6 mice show a “single” hemoglobin band, whereas the H-2 and H-1 hemizygotes show beta-sickle globin resulting from two or one copy of the transgene, respectively, in combination with the minor band of diffuse beta-globins. Homozygous sickle mice only have the characteristic band of beta-sickle globin. The complete blood counts of C57BL/6 mice, H-2, H-1, and homozygous sickle mice ( per genotype) are also shown with the hemizygous mice having intermediate values between C57BL/6 mice and homozygous sickle mice.
