FK228 Analogues Induce Fetal Hemoglobin in Human Erythroid Progenitors

Table 3

Fetal hemoglobin quantification in primary erythroid cells.

	Drug concentration	Mean	SEM	𝑃 value	Fold change
Untreated	none	0.683	0.0291	n/a	1
Cys	10 mM	0.737	0.1201	0.7773	1.079
Hemin	50 μM	1.515	0.0405	0.0001	2.218
SAHA	2000 nM	1.094	0.1049	0.0197	1.602
FK228	1.5 nM	1.676	0.0506	0.0001	2.454
JMA1	1.5 nM	0.7953	0.0849	0.2803	1.164
JMA2	1.0 nM	0.8120	0.0165	0.0183	1.188
JMA26	500 nM	1.3086	0.0535	0.0005	1.916
JMA33	1000 nM	1.7223	0.0725	0.0002	2.521