Targeting the Fanconi Anemia Pathway to Identify Tailored Anticancer Therapeutics

Figure 2

PTEN defects in cancers. Types of cancer diagnosed annually in the US (orange oval), with the estimates for PTEN deficiencies shown in each type (blue oval). An unknown percentage of tumors with PTEN deficiencies will have a defect in homologous recombination (HR) repair, predicting sensitivity to treatment with PARP1 inhibitors (green oval).