Targeting the Fanconi Anemia Pathway to Identify Tailored Anticancer Therapeutics

Table 1

Function and expression of genes synthetically lethal with FA.

Gene synthetically lethal with FA genes	Function	Expression in tumor cells
TREX2 [52]	DNA exonuclease; SAGA complex pathway	Expressed in most tumor cell lines [60]
PARP1 [52]	BER	Overexpressed in tumors, including medulloblastoma, ependymoma, HGG, melanoma, and breast cancers [35, 61–63]
PLK1 [52]	Cell-cycle progression	Over-expressed in many human tumors [64]
RAD6/HR6B [52]	Switching of DNA polymerases	Upregulated in metastatic mammary tumors [65]
CDK7 [52]	Transcription	Moderately over-expressed in tumor cell lines [66]
TP53BP1 [52]	DSB sensing; ATM activation	Underexpressed in most cases of triple negative breast cancer [67]
ATM [52]	DSB response kinase	Under-expressed in some tumors, see Figure 3
NEIL1 [52]	BER	Expression reduced in 46% of gastric cancers [68]
RAD54B [52]	HR	Known to be mutated in cancer cell lines [69, 70]
NBS1 [52]	DSB sensing; ATM activation	Over-expressed in HNSCC tumors [71]
ADH5 [6]	Formaldehyde processing	Reduced expression in melanoma cells [72]