Cobalamin and Folic Acid Status in Relation to the Etiopathogenesis of Pancytopenia in Adults at a Tertiary Care Centre in North India

Table 5

Indian studies on pancytopenia.

S. No.	Study; location	Year	Age group (years)	No. of cases	Commonest cause of pancytopenia	2nd most common cause	Other causes
1	Varma and Dash; Chandigarh [9]	1992	Adults	202	AA (40%)	MA (23%)	AML, lymphoma.
2	Tilak and Jain; Chandigarh [12]	1999	5–70	77	MA (68%)	AA (7%)	Malaria, KZ, NHL, AML, MM, TB, Waldenstrom’s macroglobulinemia
3	Khodke et al.; New Delhi [10]	2000	3–69	50	MA (44%)	AA (14%)	KZ, MM, HIV, MDS, AML, TB, Drug induced cytopenia
4	Kumar et al.; New Delhi [13]	2001	All ages	166	AA (29%)	MA (22%)	Aleukemic leukemia, lymphoma
5	Khunger et al.; New Delhi [14]	2002	2–70	250	MA (72%)	AA (14%)	Aleukemic leukemia, MDS, KZ, malaria, NHL, TB, myelofibrosis, MM
6	Santra and Das; Kolkata [11]	2010	13–65	111	AA (22%)	Hyper-splenism due to CLD (11%)	MA, SLE, Drug induced cytopenia, falciparum malaria, TB, CLL, MM, MDS, PNH, Felty’s syndrome.
7	Present study; New Delhi	2008	18–80	140	MA (60%)	Leukemia (9%), AA (8%)	HIV, TB, KZ, Malaria, MDS, CML, Gaucher’s disease, metastatic carcinoma, CLD with hypersplenism.

MA: megaloblastic anemia; AA: aplastic anemia; AML: acute myelogenous leukemia; KZ: kala-azar; MM: multiple myeloma; HIV: human immunodeficiency virus; MDS: myelodysplastic syndrome; TB: disseminated tuberculosis; NHL: non Hodgkin’s lymphoma; CLL: chronic lymphatic leukemia; PNH: paroxysmal nocturnal hemoglobinuria; CML: chronic myelogenous leukemia; CLD: chronic liver disease.