Towards a Molecular Understanding of the Fanconi Anemia Core Complex

<table>The Fanconi Anemia Pathway. A model of the Fanconi Anemia Pathway at a stalled DNA (grey) replication fork, caused by an interstrand crosslink (ICL). FANCM and its associated genes are coloured green, which assemble on DNA at the stalled replication fork. The other CC proteins are represented by blue with FANCL as the E3 ligase of the CC represented by mauve. The substrates for ubiquitination FANCD2 and FANCI are coloured gold and peach, respectively, with their associated ubiquitins represented by purple stars. The DNA repair machinery is coloured pink.</table>

Anemia

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Figure 1

Figure 1: Towards a Molecular Understanding of the Fanconi Anemia Core Complex 