Direct Comparison of the Safety and Efficacy of Ferric Carboxymaltose versus Iron Dextran in Patients with Iron Deficiency Anemia

Table 5

Changes in laboratory values.

Chemistry parameter (units)	FCM			DEX			𝑃 value^a
	𝑁	Baseline mean (SD)	Change to final value (SD)	𝑁	Baseline mean (SD)	Change to final value (SD)
ALT (SGPT) (U/L)	82	16.0 (7.09)	5.6 (9.80)	76	17.2 (12.72)	2.1 (12.77)	0.052
AST (SGOT) (U/L)	82	20.0 (7.94)	3.1 (11.41)	76	21.0 (10.04)	−0.4 (10.93)	0.051
Albumin (g/dL)	82	3.83 (0.499)	0.14 (0.313)	76	3.77 (0.446)	0.13 (0.373)	0.930
Alkaline phosphatase (U/L)	82	76.2 (36.29)	11.3 (24.40)	76	81.7 (34.46)	3.6 (16.88)	0.023
C-reactive protein (mg/dL)	82	0.7356 (1.38596)	−0.1090 (1.19793)	76	0.6104 (1.02749)	0.1315 (0.52244)	0.109
Calcium (mg/dL)	82	9.44 (0.543)	0.06 (0.412)	76	9.49 (0.469)	0.15 (0.542)	0.233
Creatinine (mg/L)	82	0.88 (0.738)	−0.04 (0.324)	76	0.80 (0.203)	−0.02 (0.095)	0.531
GGT (U/L)	82	23.1 (24.21)	8.3 (25.50)	76	24.4 (26.24)	6.5 (13.20)	0.573
LDH (U/L)	82	168.0 (39.75)	−1.9 (29.17)	76	171.4 (34.45)	−3.8 (25.35)	0.661
Magnesium (mg/dL)	82	2.06 (0.198)	0.00 (0.187)	76	2.08 (0.218)	−0.04 (0.180)	0.227
Phosphorus (mg/dL)	82	3.71 (0.712)	−0.78 (0.770)	76	3.62 (0.502)	0.22 (0.580)	≤0.001
Bicarbonate (mEq/L)	82	21.37 (3.073)	−0.19 (4.064)	76	21.35 (3.282)	−0.02 (2.845)	0.770
Chloride (mEq/L)	82	104.8 (4.31)	0.2 (3.63)	76	105.4 (3.57)	−0.4 (3.35)	0.281
Glucose (mg/dL)	82	115.7 (60.83)	−6.7 (43.09)	76	111.4 (55.87)	−6.6 (35.87)	0.976
Potassium (mEq/L)	82	4.20 (0.473)	−0.03 (0.412)	76	4.27 (0.408)	−0.05 (0.495)	0.789
Sodium (mEq/L)	82	141.5 (3.71)	−0.1 (3.85)	76	141.3 (3.34)	0.8 (3.68)	0.141
Total bilirubin (mg/dL)	82	0.33 (0.143)	0.03 (0.142)	76	0.34 (0.222)	0.01 (0.125)	0.486
Urea nitrogen (mg/dL)	82	16.5 (20.88)	−0.8 (12.48)	76	14.6 (6.03)	0.1 (4.20)	0.546

^a𝑃 value for difference between change for FCM versus DEX using a 1-way ANOVA.