Hematological Indices for Differential Diagnosis of Beta Thalassemia Trait and Iron Deficiency Anemia

Table 4

Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and Youden’s index of twelve indices to discriminate between β-TT and IDA in 290 children.

Indices	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	Youden’s index
Mentzer
β-TT	98.7	82.3	86.3	98.2	81
IDA	82.3	98.7	98.2	86.3
RBC count
β-TT	94.8	70.5	78.4	92.3	65.3
IDA	70.5	94.8	92.3	78.4
RDWI
β-TT	83.1	76.4	80	80	59.5
IDA	76.4	83.1	80	80
Shine and Lal
β-TT	100	10.2	55	100	10.2
IDA	10.2	100	100	55
Srivastava
β-TT	85.7	72	77.6	81.6	57.7
IDA	72	85.7	81.6	77.6
Green and King
β-TT	83.1	73.5	77.6	79.3	56.6
IDA	73.5	83.1	79.3	77.6
Sirdah
β-TT	85.7	79.4	82.5	83	65
IDA	79.4	85.7	83	82.5
Ehsani
β-TT	94.8	73.5	80.2	92.5	68.3
IDA	73.5	94.8	92.5	80.2
England and Fraser
β-TT	66.2	85.3	83.6	69	51.4
IDA	85.3	66.2	69	83.6
Ricerca
β-TT	100	14.7	57	100	14.7
IDA	14.7	100	100	57
MDHL
β-TT	76	58.8	76.6	69	34.8
IDA	58.8	76	69	76.6
MCHD
β-TT	77.9	27.9	55	52.7	5.8
IDA	27.9	77.9	52.7	55