Molecular Characterization and Genotype-Phenotype Correlation of G6PD Mutations in Five Ethnicities of Northern Vietnam

Table 1

Participant characteristics in this study.

	Male	Female	Total	p
Age
<1 month	244 (71.98)	24 (7.08)	268 (79.06)	0.0089
1–6months	50 (14.75)	9 (2.61)	59 (17.41)
>6–12 months	5 (1.48)	1 (0.29)	6 (1.77)
>12–24 months	1 (0.29)	2 (0.59)	3 (0.88)
>24 months	2 (0.59)	1 (0.29)	3 (0.88)
N	302	37	339
Enzyme activity (IU/g·Hb)
Average	1.27 ± 1.06	2.98 ± 1.57		<0.0001
The G6PD deficiency level of participants
High (<0.6  U/g·Hb)	78 (23.01)	1 (0.29)	79 (23.30)	<0.0001
Medium (0.6–3.6 IU/g·Hb)	212 (62.54)	21 (6.20)	233 (68.74)
Low (3.6–9 IU/g·Hb)	12 (3.54)	15 (4.42)	27 (7.96)
N	302	37	339
Genotype
No mutation	11 (3.25)	0	11 (3.25)	<0.0001
Homozygous	0	8 (2.36)	8 (2.36)
Hemizygous	291 (85.84)	0	291 (85.84)
Heterozygous	0	29 (8.55)	29 (8.55)
N	302	37	339